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Whei-Mei Teresa Fan
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  • Publications
  • 531 BioPharm Complex
Position(s): 
Professor, Edith D. Gardner Chair in Cancer Research
Affiliation(s): 
Toxicology and Cancer Biology
PubMed Publications: 
  • Wang, Q.;Zhou, Y.;Rychahou, P.;Fan, T.W.;Lane, A.N.;Weiss, H.L.;Evers, B.M. "Ketogenesis contributes to intestinal cell differentiation." Cell death and differentiation 24, 3 (2017): 458-468. [PubMed Link] | [ Full text ]
  • Zhao, J.;Li, J.;Fan, T.W.M.;Hou, S.X. "Glycolytic reprogramming through PCK2 regulates tumor initiation of prostate cancer cells." Oncotarget (2017): [PubMed Link] | [ Full text ]
  • Bruntz, R.C.;Lane, A.N.;Higashi, R.M.;Fan, T.W. "Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM)." The Journal of biological chemistry 292, 28 (2017): 11601-11609. [PubMed Link] | [ Full text ]
  • Yang, Y.;Fan, T.W.;Lane, A.N.;Higashi, R.M. "Chloroformate derivatization for tracing the fate of Amino acids in cells and tissues by multiple stable isotope resolved metabolomics (mSIRM)." Analytica chimica acta 976, (2017): 63-73. [PubMed Link] | [ Full text ]
  • Lane, A.N.;Tan, J.;Wang, Y.;Yan, J.;Higashi, R.M.;Fan, T.W. "Probing the metabolic phenotype of breast cancer cells by multiple tracer stable isotope resolved metabolomics." Metabolic engineering (2017): [PubMed Link] | [ Full text ]
  • Lane, A.N.;Fan, T.W. "NMR-based Stable Isotope Resolved Metabolomics in systems biochemistry." Archives of biochemistry and biophysics 628, (2017): 123-131. [PubMed Link] | [ Full text ]
  • Li, J.;Song, J.;Zaytseva, Y.Y.;Liu, Y.;Rychahou, P.;Jiang, K.;Starr, M.E.;Kim, J.T.;Harris, J.W.;Yiannikouris, F.B.;Katz, W.S.;Nilsson, P.M.;Orho-Melander, M.;Chen, J.;Zhu, H.;Fahrenholz, T.;Higashi, R.M.;Gao, T.;Morris, A.J.;Cassis, L.A.;Fan, T.W.;Weiss, H.L.;Dobner, P.R.;Melander, O.;Jia, J.;Evers, B.M. "An obligatory role for neurotensin in high-fat-diet-induced obesity." Nature 533, 7603 (2016): 411-5. [PubMed Link] | [ Full text ]
  • Liu, M.;Luo, F.;Ding, C.;Albeituni, S.;Hu, X.;Ma, Y.;Cai, Y.;McNally, L.;Sanders, M.A.;Jain, D.;Kloecker, G.;Bousamra M, 2nd;Zhang, H.G.;Higashi, R.M.;Lane, A.N.;Fan, T.W.;Yan, J. "Correction: Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype." Journal of immunology (Baltimore, Md. : 1950) 196, 9 (2016): 3968. [PubMed Link] | [ Full text ]
  • Lane, A.N.;Higashi, R.M.;Fan, T.W. "Preclinical models for interrogating drug action in human cancers using Stable Isotope Resolved Metabolomics (SIRM)." Metabolomics : Official journal of the Metabolomic Society 12, 7 (2016): [PubMed Link] |
  • Fan, T.W.;Warmoes, M.O.;Sun, Q.;Song, H.;Turchan-Cholewo, J.;Martin, J.T.;Mahan, A.;Higashi, R.M.;Lane, A.N. "Distinctly perturbed metabolic networks underlie differential tumor tissue damages induced by immune modulator β-glucan in a two-case ex vivo non-small-cell lung cancer study." Cold Spring Harbor molecular case studies 2, 4 (2016): a000893. [PubMed Link] | [ Full text ]
  • Saxena, N.;Maio, N.;Crooks, D.R.;Ricketts, C.J.;Yang, Y.;Wei, M.H.;Fan, T.W.;Lane, A.N.;Sourbier, C.;Singh, A.;Killian, J.K.;Meltzer, P.S.;Vocke, C.D.;Rouault, T.A.;Linehan, W.M. "SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery." Journal of the National Cancer Institute 108, 1 (2016): [PubMed Link] | [ Full text ]
  • Fan, T.W.;Lane, A.N.;Higashi, R.M. "Stable Isotope Resolved Metabolomics Studies <i>in Ex Vivo</i> TIssue Slices." Bio-protocol 6, 3 (2016): [PubMed Link] |
  • Fan, T.W.;Lane, A.N. "Applications of NMR spectroscopy to systems biochemistry." Progress in nuclear magnetic resonance spectroscopy 92-93, (2016): 18-53. [PubMed Link] | [ Full text ]
  • Saxena, N.;Maio, N.;Crooks, D.R.;Ricketts, C.J.;Yang, Y.;Wei, M.H.;Fan, T.W.;Lane, A.N.;Sourbier, C.;Singh, A.;Killian, J.K.;Meltzer, P.S.;Vocke, C.D.;Rouault, T.A.;Linehan, W.M. "SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery." Journal of the National Cancer Institute 108, 1 (2015): [PubMed Link] |
  • Lane, A.N.;Yan, J.;Fan, T.W. "<sup>13</sup>C Tracer Studies of Metabolism in Mouse Tumor Xenografts." Bio-protocol 5, 22 (2015): [PubMed Link] |
  • Liu, M.;Luo, F.;Ding, C.;Albeituni, S.;Hu, X.;Ma, Y.;Cai, Y.;McNally, L.;Sanders, M.A.;Jain, D.;Kloecker, G.;Bousamra M, 2nd;Zhang, H.G.;Higashi, R.M.;Lane, A.N.;Fan, T.W.;Yan, J. "Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype." Journal of immunology (Baltimore, Md. : 1950) 195, 10 (2015): 5055-65. [PubMed Link] | [ Full text ]
  • Lane, A.N.;Arumugam, S.;Lorkiewicz, P.K.;Higashi, R.M.;Laulhé, S.;Nantz, M.H.;Moseley, H.N.;Fan, T.W. "Chemoselective detection and discrimination of carbonyl-containing compounds in metabolite mixtures by 1H-detected 15N nuclear magnetic resonance." Magnetic resonance in chemistry : MRC 53, 5 (2015): 337-43. [PubMed Link] | [ Full text ]
  • Lane, A.N.;Fan, T.W. "Regulation of mammalian nucleotide metabolism and biosynthesis." Nucleic acids research 43, 4 (2015): 2466-85. [PubMed Link] | [ Full text ]
  • Sellers, K.;Fox, M.P.;Bousamra M, 2nd;Slone, S.P.;Higashi, R.M.;Miller, D.M.;Wang, Y.;Yan, J.;Yuneva, M.O.;Deshpande, R.;Lane, A.N.;Fan, T.W. "Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation." The Journal of clinical investigation 125, 2 (2015): 687-98. [PubMed Link] | [ Full text ]
  • Tarrado-Castellarnau, M.;Cortés, R.;Zanuy, M.;Tarragó-Celada, J.;Polat, I.H.;Hill, R.;Fan, T.W.;Link, W.;Cascante, M. "Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition." Pharmacological research 102, (2015): 218-34. [PubMed Link] | [ Full text ]
  • Xie, H.;Hanai, J.;Ren, J.G.;Kats, L.;Burgess, K.;Bhargava, P.;Signoretti, S.;Billiard, J.;Duffy, K.J.;Grant, A.;Wang, X.;Lorkiewicz, P.K.;Schatzman, S.;Bousamra M, 2nd;Lane, A.N.;Higashi, R.M.;Fan, T.W.;Pandolfi, P.P.;Sukhatme, V.P.;Seth, P. "Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells." Cell metabolism 19, 5 (2014): 795-809. [PubMed Link] | [ Full text ]
  • Ren, J.G.;Seth, P.;Clish, C.B.;Lorkiewicz, P.K.;Higashi, R.M.;Lane, A.N.;Fan, T.W.;Sukhatme, V.P. "Knockdown of malic enzyme 2 suppresses lung tumor growth, induces differentiation and impacts PI3K/AKT signaling." Scientific reports 4, (2014): 5414. [PubMed Link] | [ Full text ]
  • Gori, S.S.;Lorkiewicz, P.;Ehringer, D.S.;Belshoff, A.C.;Higashi, R.M.;Fan, T.W.;Nantz, M.H. "Profiling thiol metabolites and quantification of cellular glutathione using FT-ICR-MS spectrometry." Analytical and bioanalytical chemistry 406, 18 (2014): 4371-9. [PubMed Link] | [ Full text ]
  • Guin, S.;Pollard, C.;Ru, Y.;Ritterson Lew, C.;Duex, J.E.;Dancik, G.;Owens, C.;Spencer, A.;Knight, S.;Holemon, H.;Gupta, S.;Hansel, D.;Hellerstein, M.;Lorkiewicz, P.;Lane, A.N.;Fan, T.W.;Theodorescu, D. "Role in tumor growth of a glycogen debranching enzyme lost in glycogen storage disease." Journal of the National Cancer Institute 106, 5 (2014): [PubMed Link] | [ Full text ]
  • Higashi, R.M.;Fan, T.W.;Lorkiewicz, P.K.;Moseley, H.N.;Lane, A.N. "Stable isotope-labeled tracers for metabolic pathway elucidation by GC-MS and FT-MS." Methods in molecular biology (Clifton, N.J.) 1198, (2014): 147-67. [PubMed Link] | [ Full text ]
  • Mitchell, J.M.;Fan, T.W.;Lane, A.N.;Moseley, H.N. "Development and in silico evaluation of large-scale metabolite identification methods using functional group detection for metabolomics." Frontiers in genetics 5, (2014): 237. [PubMed Link] | [ Full text ]
  • Dong, C.;Yuan, T.;Wu, Y.;Wang, Y.;Fan, T.W.;Miriyala, S.;Lin, Y.;Yao, J.;Shi, J.;Kang, T.;Lorkiewicz, P.;St Clair, D.;Hung, M.C.;Evers, B.M.;Zhou, B.P. "Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer." Cancer cell 23, 3 (2013): 316-31. [PubMed Link] | [ Full text ]
  • Yang, Y.;Lane, A.N.;Ricketts, C.J.;Sourbier, C.;Wei, M.H.;Shuch, B.;Pike, L.;Wu, M.;Rouault, T.A.;Boros, L.G.;Fan, T.W.;Linehan, W.M. "Metabolic reprogramming for producing energy and reducing power in fumarate hydratase null cells from hereditary leiomyomatosis renal cell carcinoma." PloS one 8, 8 (2013): e72179. [PubMed Link] | [ Full text ]
  • Muenyi, C.S.;Pinhas, A.R.;Fan, T.W.;Brock, G.N.;Helm, C.W.;States, J.C. "Sodium arsenite ± hyperthermia sensitizes p53-expressing human ovarian cancer cells to cisplatin by modulating platinum-DNA damage responses." Toxicological sciences : an official journal of the Society of Toxicology 127, 1 (2012): 139-49. [PubMed Link] | [ Full text ]
  • Fan, T.W.;Lorkiewicz, P.K.;Sellers, K.;Moseley, H.N.;Higashi, R.M.;Lane, A.N. "Stable isotope-resolved metabolomics and applications for drug development." Pharmacology & therapeutics 133, 3 (2012): 366-91. [PubMed Link] | [ Full text ]
  • Liu, W.;Le, A.;Hancock, C.;Lane, A.N.;Dang, C.V.;Fan, T.W.;Phang, J.M. "Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC." Proceedings of the National Academy of Sciences of the United States of America 109, 23 (2012): 8983-8. [PubMed Link] | [ Full text ]
  • Fan, T.W.;Tan, J.;McKinney, M.M.;Lane, A.N. "Stable Isotope Resolved Metabolomics Analysis of Ribonucleotide and RNA Metabolism in Human Lung Cancer Cells." Metabolomics : Official journal of the Metabolomic Society 8, 3 (2012): 517-527. [PubMed Link] |
  • Le, A.;Lane, A.N.;Hamaker, M.;Bose, S.;Gouw, A.;Barbi, J.;Tsukamoto, T.;Rojas, C.J.;Slusher, B.S.;Zhang, H.;Zimmerman, L.J.;Liebler, D.C.;Slebos, R.J.;Lorkiewicz, P.K.;Higashi, R.M.;Fan, T.W.;Dang, C.V. "Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells." Cell metabolism 15, 1 (2012): 110-21. [PubMed Link] | [ Full text ]
  • Yuneva, M.O.;Fan, T.W.;Allen, T.D.;Higashi, R.M.;Ferraris, D.V.;Tsukamoto, T.;Matés, J.M.;Alonso, F.J.;Wang, C.;Seo, Y.;Chen, X.;Bishop, J.M. "The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type." Cell metabolism 15, 2 (2012): 157-70. [PubMed Link] | [ Full text ]
  • Mattingly, S.J.;Xu, T.;Nantz, M.H.;Higashi, R.M.;Fan, T.W. "A Carbonyl Capture Approach for Profiling Oxidized Metabolites in Cell Extracts." Metabolomics : Official journal of the Metabolomic Society 8, 6 (2012): 989-996. [PubMed Link] |
  • Lorkiewicz, P.;Higashi, R.M.;Lane, A.N.;Fan, T.W. "High information throughput analysis of nucleotides and their isotopically enriched isotopologues by direct-infusion FTICR-MS." Metabolomics : Official journal of the Metabolomic Society 8, 5 (2012): 930-939. [PubMed Link] |
  • Gracey, A.Y.;Lee, T.H.;Higashi, R.M.;Fan, T. "Hypoxia-induced mobilization of stored triglycerides in the euryoxic goby Gillichthys mirabilis." The Journal of experimental biology 214, Pt 18 (2011): 3005-12. [PubMed Link] | [ Full text ]
  • Moseley, H.N.;Lane, A.N.;Belshoff, A.C.;Higashi, R.M.;Fan, T.W. "A novel deconvolution method for modeling UDP-N-acetyl-D-glucosamine biosynthetic pathways based on (13)C mass isotopologue profiles under non-steady-state conditions." BMC biology 9, (2011): 37. [PubMed Link] | [ Full text ]
  • Lane, A.N.;Fan, T.W.;Bousamra M, 2nd;Higashi, R.M.;Yan, J.;Miller, D.M. "Stable isotope-resolved metabolomics (SIRM) in cancer research with clinical application to nonsmall cell lung cancer." Omics : a journal of integrative biology 15, 3 (2011): 173-82. [PubMed Link] | [ Full text ]
  • Muenyi, C.S.;States, V.A.;Masters, J.H.;Fan, T.W.;Helm, C.W.;States, J.C. "Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal chemotherapy (HIPEC)." Journal of ovarian research 4, (2011): 9. [PubMed Link] | [ Full text ]
  • Fan, T.W.;Lane, A.N.;Higashi, R.M.;Yan, J. "Stable isotope resolved metabolomics of lung cancer in a SCID mouse model." Metabolomics : Official journal of the Metabolomic Society 7, 2 (2011): 257-269. [PubMed Link] |
  • Fan, T.W.;Lane, A.N. "NMR-based stable isotope resolved metabolomics in systems biochemistry." Journal of biomolecular NMR 49, 3-4 (2011): 267-80. [PubMed Link] | [ Full text ]
  • Selivanov, V.A.;Vizán, P.;Mollinedo, F.;Fan, T.W.;Lee, P.W.;Cascante, M. "Edelfosine-induced metabolic changes in cancer cells that precede the overproduction of reactive oxygen species and apoptosis." BMC systems biology 4, (2010): 135. [PubMed Link] | [ Full text ]
  • Fan, T.W.;Yuan, P.;Lane, A.N.;Higashi, R.M.;Wang, Y.;Hamidi, A.B.;Zhou, R.;Guitart, X.;Chen, G.;Manji, H.K.;Kaddurah-Daouk, R. "Stable isotope-resolved metabolomic analysis of lithium effects on glial-neuronal metabolism and interactions." Metabolomics : Official journal of the Metabolomic Society 6, 2 (2010): 165-179. [PubMed Link] |
  • Lane, A.N.;Fan, T.W.;Xie, Z.;Moseley, H.N.;Higashi, R.M. "Isotopomer analysis of lipid biosynthesis by high resolution mass spectrometry and NMR." Analytica chimica acta 651, 2 (2009): 201-8. [PubMed Link] | [ Full text ]
  • Fan, T.W.;Lane, A.N.;Higashi, R.M.;Farag, M.A.;Gao, H.;Bousamra, M.;Miller, D.M. "Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM)." Molecular cancer 8, (2009): 41. [PubMed Link] | [ Full text ]
  • Lane, A.N.;Fan, T.W.;Higashi, R.M.;Tan, J.;Bousamra, M.;Miller, D.M. "Prospects for clinical cancer metabolomics using stable isotope tracers." Experimental and molecular pathology 86, 3 (2009): 165-73. [PubMed Link] | [ Full text ]
  • Fan, T.W.;Lane, A.N.;Higashi, R.M.;Bousamra M, 2nd;Kloecker, G.;Miller, D.M. "Metabolic profiling identifies lung tumor responsiveness to erlotinib." Experimental and molecular pathology 87, 1 (2009): 83-6. [PubMed Link] | [ Full text ]
  • Fan, T.W.;Kucia, M.;Jankowski, K.;Higashi, R.M.;Ratajczak, J.;Ratajczak, M.Z.;Lane, A.N. "Rhabdomyosarcoma cells show an energy producing anabolic metabolic phenotype compared with primary myocytes." Molecular cancer 7, (2008): 79. [PubMed Link] | [ Full text ]
  • McNeely, S.C.;Belshoff, A.C.;Taylor, B.F.;Fan, T.W.;McCabe MJ, J.;Pinhas, A.R.;States, J.C. "Sensitivity to sodium arsenite in human melanoma cells depends upon susceptibility to arsenite-induced mitotic arrest." Toxicology and applied pharmacology 229, 2 (2008): 252-61. [PubMed Link] | [ Full text ]
  • Lane, A.N.;Fan, T.W.;Higashi, R.M. "Stable isotope-assisted metabolomics in cancer research." IUBMB life 60, 2 (2008): 124-9. [PubMed Link] | [ Full text ]
  • Fan, T.;Elgourt, T. "Pain management pharmacy service in a community hospital." American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 65, 16 (2008): 1560-5. [PubMed Link] | [ Full text ]
  • Lane, A.N.;Fan, T.W.;Higashi, R.M. "Isotopomer-based metabolomic analysis by NMR and mass spectrometry." Methods in cell biology 84, (2008): 541-88. [PubMed Link] | [ Full text ]
  • Sumner, L.W.;Amberg, A.;Barrett, D.;Beale, M.H.;Beger, R.;Daykin, C.A.;Fan, T.W.;Fiehn, O.;Goodacre, R.;Griffin, J.L.;Hankemeier, T.;Hardy, N.;Harnly, J.;Higashi, R.;Kopka, J.;Lane, A.N.;Lindon, J.C.;Marriott, P.;Nicholls, A.W.;Reily, M.D.;Thaden, J.J.;Viant, M.R. "Proposed minimum reporting standards for chemical analysis Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI)." Metabolomics : Official journal of the Metabolomic Society 3, 3 (2007): 211-221. [PubMed Link] |
  • Podrabsky, J.E.;Lopez, J.P.;Fan, T.W.;Higashi, R.;Somero, G.N. "Extreme anoxia tolerance in embryos of the annual killifish Austrofundulus limnaeus: insights from a metabolomics analysis." The Journal of experimental biology 210, Pt 13 (2007): 2253-66. [PubMed Link] | [ Full text ]
  • MSI Board, M.;Sansone, S.A.;Fan, T.;Goodacre, R.;Griffin, J.L.;Hardy, N.W.;Kaddurah-Daouk, R.;Kristal, B.S.;Lindon, J.;Mendes, P.;Morrison, N.;Nikolau, B.;Robertson, D.;Sumner, L.W.;Taylor, C.;Werf, M.;Ommen, B.;Fiehn, O. "The metabolomics standards initiative." Nature biotechnology 25, 8 (2007): 846-8. [PubMed Link] | [ Full text ]
  • Rose, W.L.;Nisbet, R.M.;Green, P.G.;Norris, S.;Fan, T.;Smith, E.H.;Cherr, G.N.;Anderson, S.L. "Using an integrated approach to link biomarker responses and physiological stress to growth impairment of cadmium-exposed larval topsmelt." Aquatic toxicology (Amsterdam, Netherlands) 80, 3 (2006): 298-308. [PubMed Link] | [ Full text ]
  • Fan, T.W.;Higashi, R.M.;Lane, A.N. "Integrating metabolomics and transcriptomics for probing SE anticancer mechanisms." Drug metabolism reviews 38, 4 (2006): 707-32. [PubMed Link] | [ Full text ]
  • Teh, S.J.;Deng, X.;Deng, D.F.;Teh, F.C.;Hung, S.S.;Fan, T.W.;Liu, J.;Higashi, R.M. "Chronic effects of dietary selenium on juvenile Sacramento splittail (Pogonichthys macrolepidotus)." Environmental science & technology 38, 22 (2004): 6085-93. [PubMed Link] |
  • Fan, T.W.;Lane, A.N.;Higashi, R.M. "An electrophoretic profiling method for thiol-rich phytochelatins and metallothioneins." Phytochemical analysis : PCA 15, 3 (2004): 175-83. [PubMed Link] | [ Full text ]
  • Fan, T.W.;Lane, A.N.;Higashi, R.M. "The promise of metabolomics in cancer molecular therapeutics." Current opinion in molecular therapeutics 6, 6 (2004): 584-92. [PubMed Link] |
  • Ramos, A.;Lane, A.N.;Hollingworth, D.;Fan, T.W. "Secondary structure and stability of the selenocysteine insertion sequences (SECIS) for human thioredoxin reductase and glutathione peroxidase." Nucleic acids research 32, 5 (2004): 1746-55. [PubMed Link] | [ Full text ]
  • Fan, T.W.;Teh, S.J.;Hinton, D.E.;Higashi, R.M. "Selenium biotransformations into proteinaceous forms by foodweb organisms of selenium-laden drainage waters in California." Aquatic toxicology (Amsterdam, Netherlands) 57, 1-2 (2002): 65-84. [PubMed Link] | [ Full text ]
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