Whei-Mei Teresa Fan | Toxicology and Cancer Biology

Whei-Mei Teresa Fan

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531 BioPharm Complex

Position(s):

Professor, Edith D. Gardner Chair in Cancer Research

Affiliation(s):

Toxicology and Cancer Biology

PubMed Publications:

Zhong, Y.; Mohan, K.; Liu, J.; Al-Attar, A.; Lin, P.; Flight, RM ; Sun, Q.; Warmoes, MO ; Deshpande, RR ; Liu, H.; Jung, KS ; Mitov, MI ; Lin, N.; Butterfield, DA ; Lu, S.; Liu, J.; Moseley, HNB ; Fan, TWM ; Kleinman, ME ; Wang, QJ "Loss of CLN3, the gene mutated in juvenile neuronal ceroid lipofuscinosis, leads to metabolic impairment and autophagy induction in retinal pigment epithelium." Biochimica et biophysica acta. Molecular basis of disease 1866, 10 (2020): 165883. [PubMed Link] | [ Full text ]
Zhang, Y.; Zhang, X.; Lane, AN ; Fan, TW ; Liu, J. "Inferring Gene Regulatory Networks of Metabolic Enzymes Using Gradient Boosted Trees." IEEE journal of biomedical and health informatics 24, 5 (2020): 1528-1536. [PubMed Link] | [ Full text ]
Reyes-Caballero, H ; Rao, X.; Sun, Q.; Warmoes, MO ; Lin, P.; Sussan, TE ; Park, B.; Fan, TW ; Maiseyeu, A.; Rajagopalan, S.; Girnun, GD ; Biswal, S. "Author Correction: Air pollution-derived particulate matter dysregulates hepatic Krebs cycle, glucose and lipid metabolism in mice." Scientific reports 10, 1 (2020): 5082. [PubMed Link] | [ Full text ]
Chen, CM ; Yun, AG ; Fan, T. "Efficacy of Liposomal Bupivacaine versus Ropivacaine in Adductor Canal Block for Total Knee Arthroplasty." The journal of knee surgery (2020): [PubMed Link] | [ Full text ]
Fan, TW ; Higashi, RM ; Chernayavskaya, Y ; Lane, AN "Resolving Metabolic Heterogeneity in Experimental Models of the Tumor Microenvironment from a Stable Isotope Resolved Metabolomics Perspective." Metabolites 10, 6 (2020): [PubMed Link] | [ Full text ]
Lane, AN ; Higashi, RM ; Fan, TW "Metabolic reprogramming in tumors: Contributions of the tumor microenvironment." Genes & diseases 7, 2 (2020): 185-198. [PubMed Link] | [ Full text ]
Wu, H.; Reizel, T ; Wang, YJ ; Lapiro, JL ; Kren, BT ; Schug, J.; Rao, S.; Morgan, A ; Herman, A.; Shekels, LL ; Rassette, MS ; Lane, AN ; Cassel, T.; Fan, TWM ; Manivel, JC ; Gunewardena, S ; Apte, U ; Sicinski, P ; Kaestner, KH ; Albrecht, JH "A negative reciprocal regulatory axis between cyclin D1 and HNF4α modulates cell cycle progression and metabolism in the liver." Proceedings of the National Academy of Sciences of the United States of America 117, 29 (2020): 17177-17186. [PubMed Link] | [ Full text ]
Wang, T.; Gnanaprakasam, JNR ; Chen, X.; Kang, S.; Xu, X.; Sun, H.; Liu, L.; Rodgers, H.; Miller, E.; Cassel, TA ; Sun, Q.; Vicente-Muñoz, S ; Warmoes, MO ; Lin, P.; Piedra-Quintero, ZL ; Guerau-de-Arellano, M ; Cassady, KA ; Zheng, SG ; Yang, J.; Lane, AN ; Song, X.; Fan, TW ; Wang, R. "Inosine is an alternative carbon source for CD8+-T-cell function under glucose restriction." Nature metabolism 2, 7 (2020): 635-647. [PubMed Link] | [ Full text ]
Huang, Z.; Lane, AN ; Fan, TW ; Higashi, RM ; Weiss, HL ; Yin, X.; Wang, C. "Differential Abundance Analysis with Bayes Shrinkage Estimation of Variance (DASEV) for Zero-Inflated Proteomic and Metabolomic Data." Scientific reports 10, 1 (2020): 876. [PubMed Link] | [ Full text ]
Palmieri, EM ; Gonzalez-Cotto, M ; Baseler, WA ; Davies, LC ; Ghesquière, B ; Maio, N.; Rice, CM ; Rouault, TA ; Cassel, T.; Higashi, RM ; Lane, AN ; Fan, TW ; Wink, DA ; McVicar, DW "Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase." Nature communications 11, 1 (2020): 698. [PubMed Link] | [ Full text ]
Xiao, GG ; Zhang, Z.; Lu, B.; Wang, H.; Fan, TW ; Boros, LG ; Gao, P.; Pan, Y.; Go, VLW "Proceedings of the 3rd International Conference for Cancer Metabolism and Therapy, October 12-14, 2018, Shanghai, China." Pancreas 49, 2 (2020): 149-157. [PubMed Link] | [ Full text ]
Sun, Q.; Fan, TW ; Lane, AN ; Higashi, RM "Applications of Chromatography-Ultra High-Resolution MS for Stable Isotope-Resolved Metabolomics (SIRM) Reconstruction of Metabolic Networks." Trends in analytical chemistry : TRAC 123, (2020): [PubMed Link] |
Sengupta, D.; Cassel, T.; Teng, KY ; Aljuhani, M ; Chowdhary, VK ; Hu, P.; Zhang, X.; Fan, TW ; Ghoshal, K "Regulation of hepatic glutamine metabolism by miR-122." Molecular metabolism 34, (2020): 174-186. [PubMed Link] | [ Full text ]
Selivanov, VA ; Marin, S ; Tarragó-Celada, J.; Lane, AN ; Higashi, RM ; Fan, TW ; de Atauri, P ; Cascante, M. "Software Supporting a Workflow of Quantitative Dynamic Flux Maps Estimation in Central Metabolism from SIRM Experimental Data." Methods in molecular biology (Clifton, N.J.) 2088, (2020): 271-298. [PubMed Link] | [ Full text ]
Panarsky, R ; Crooks, DR ; Lane, AN ; Yang, Y.; Cassel, TA ; Fan, TW ; Linehan, WM ; Moscow, JA "Fumarate hydratase-deficient renal cell carcinoma cells respond to asparagine by activation of the unfolded protein response and stimulation of the hexosamine biosynthetic pathway." Cancer & metabolism 8, (2020): 7. [PubMed Link] | [ Full text ]
Fan, TWM ; Bruntz, RC ; Yang, Y.; Song, H.; Chernyavskaya, Y ; Deng, P.; Zhang, Y.; Shah, PP ; Beverly, LJ ; Qi, Z.; Mahan, AL ; Higashi, RM ; Dang, CV ; Lane, AN "De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues." The Journal of biological chemistry 294, 36 (2019): 13464-13477. [PubMed Link] | [ Full text ]
Li, Y.; Fan, TWM ; Lane, AN ; Kang, WY ; Arnold, SM ; Stromberg, AJ ; Wang, C.; Chen, L. "SDA: a semi-parametric differential abundance analysis method for metabolomics and proteomics data." BMC bioinformatics 20, 1 (2019): 501. [PubMed Link] | [ Full text ]
Wen, YA ; Xiong, X.; Scott, T.; Li, AT ; Wang, C.; Weiss, HL ; Tan, L.; Bradford, E ; Fan, TWM ; Chandel, NS ; Barrett, TA ; Gao, T. "The mitochondrial retrograde signaling regulates Wnt signaling to promote tumorigenesis in colon cancer." Cell death and differentiation 26, 10 (2019): 1955-1969. [PubMed Link] | [ Full text ]
Kang, WY ; Thompson, PT ; El-Amouri, SS ; Fan, TWM ; Lane, AN ; Higashi, RM "Improved segmented-scan spectral stitching for stable isotope resolved metabolomics (SIRM) by ultra-high-resolution Fourier transform mass spectrometry." Analytica chimica acta 1080, (2019): 104-115. [PubMed Link] | [ Full text ]
Reyes-Caballero, H ; Rao, X.; Sun, Q.; Warmoes, MO ; Lin, P.; Sussan, TE ; Park, B.; Fan, TW ; Maiseyeu, A.; Rajagopalan, S.; Girnun, GD ; Biswal, S. "Air pollution-derived particulate matter dysregulates hepatic Krebs cycle, glucose and lipid metabolism in mice." Scientific reports 9, 1 (2019): 17423. [PubMed Link] | [ Full text ]
Rao, TN ; Hansen, N ; Hilfiker, J ; Rai, S.; Majewska, JM ; Leković, D ; Gezer, D ; Andina, N ; Galli, S.; Cassel, T.; Geier, F ; Delezie, J ; Nienhold, R ; Hao-Shen, H ; Beisel, C ; Di Palma, S ; Dimeloe, S ; Trebicka, J ; Wolf, D.; Gassmann, M.; Fan, TW ; Lane, AN ; Handschin, C ; Dirnhofer, S ; Kröger, N ; Hess, C ; Radimerski, T ; Koschmieder, S.; Čokić, VP ; Skoda, RC "JAK2-mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms." Blood 134, 21 (2019): 1832-1846. [PubMed Link] | [ Full text ]
Bruntz, RC ; Belshoff, AC ; Zhang, Y.; Macedo, JKA ; Higashi, RM ; Lane, AN ; Fan, TW "Inhibition of Anaplerotic Glutaminolysis Underlies Selenite Toxicity in Human Lung Cancer." Proteomics 19, 21-22 (2019): e1800486. [PubMed Link] | [ Full text ]
Lane, AN ; Higashi, RM ; Fan, TW "NMR and MS-based Stable Isotope-Resolved Metabolomics and Applications in Cancer Metabolism." Trends in analytical chemistry : TRAC 120, (2019): [PubMed Link] |
Sellers, K.; Allen, TD ; Bousamra M, 2nd ; Tan, J.; Méndez-Lucas, A.; Lin, W.; Bah, N ; Chernyavskaya, Y ; MacRae, JI ; Higashi, RM ; Lane, AN ; Fan, TW ; Yuneva, MO "Metabolic reprogramming and Notch activity distinguish between non-small cell lung cancer subtypes." British journal of cancer 121, 1 (2019): 51-64. [PubMed Link] | [ Full text ]
Kulkarni, RA ; Briney, CA ; Crooks, DR ; Bergholtz, SE ; Mushti, C ; Lockett, SJ ; Lane, AN ; Fan, TW ; Swenson, RE ; Linehan, Marston ; Meier, JL "Photoinducible Oncometabolite Detection." Chembiochem : a European journal of chemical biology 20, 3 (2019): 360-365. [PubMed Link] | [ Full text ]
Kishimoto, S ; , ; Crooks, DR ; Matsumoto, S.; Seki, T.; Oshima, N ; Merkle, H ; Lin, P.; Reed, G.; Chen, AP ; Ardenkjaer-Larsen, JH ; Munasinghe, J ; Saito, K.; Yamamoto, K.; Choyke, PL ; Mitchell, J.; Lane, AN ; Fan, TW ; Linehan, WM ; Krishna, MC "Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice." eLife 8, (2019): [PubMed Link] | [ Full text ]
Crooks, DR ; Fan, TW ; Linehan, WM "Metabolic Labeling of Cultured Mammalian Cells for Stable Isotope-Resolved Metabolomics: Practical Aspects of Tissue Culture and Sample Extraction." Methods in molecular biology (Clifton, N.J.) 1928, (2019): 1-27. [PubMed Link] | [ Full text ]
Lin, P.; Lane, AN ; Fan, TW "Stable Isotope-Resolved Metabolomics by NMR." Methods in molecular biology (Clifton, N.J.) 2037, (2019): 151-168. [PubMed Link] | [ Full text ]
Yang, Y.; Fan, TW ; Lane, AN ; Higashi, RM "Quantification of Isotopologues of Amino Acids by Multiplexed Stable Isotope-Resolved Metabolomics Using Ultrahigh-Resolution Mass Spectrometry Coupled with Direct Infusion." Methods in molecular biology (Clifton, N.J.) 2030, (2019): 57-68. [PubMed Link] | [ Full text ]
Mitchell, JM ; Flight, RM ; Wang, QJ ; Higashi, RM ; Fan, TW ; Lane, AN ; Moseley, HNB "New methods to identify high peak density artifacts in Fourier transform mass spectra and to mitigate their effects on high-throughput metabolomic data analysis." Metabolomics : Official journal of the Metabolomic Society 14, 10 (2018): 125. [PubMed Link] |
Lian, G ; , ; Wang, T.; Wu, R.; Chen, X.; Liu, L.; Shen, Y.; Yang, M.; Yang, J.; Chen, Y.; Vasiliou, V ; Cassel, TA ; Green, DR ; Liu, Y.; Fan, TW ; Wang, R. "Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation." eLife 7, (2018): [PubMed Link] | [ Full text ]
Crooks, DR ; Maio, N.; Lane, AN ; Jarnik, M.; Higashi, RM ; Haller, RG ; Yang, Y.; Fan, TW ; Linehan, WM ; Rouault, TA "Acute loss of iron-sulfur clusters results in metabolic reprogramming and generation of lipid droplets in mammalian cells." The Journal of biological chemistry 293, 21 (2018): 8297-8311. [PubMed Link] | [ Full text ]
Zaytseva, YY ; Rychahou, PG ; Le, AT ; Scott, TL ; Flight, RM ; Kim, JT ; Harris, J.; Liu, J.; Wang, C.; Morris, AJ ; Sivakumaran, TA ; Fan, T.; Moseley, H.; Gao, T.; Lee, EY ; Weiss, HL ; Heuer, TS ; Kemble, G.; Evers, M. "Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer." Oncotarget 9, 37 (2018): 24787-24800. [PubMed Link] | [ Full text ]
Kuperman, RG ; Checkai, RT ; Simini, M.; Phillips, CT ; Higashi, RM ; Fan, TW ; Sappington, K. "Selenium toxicity to survival and reproduction of Collembola and Enchytraeids in a sandy loam soil." Environmental toxicology and chemistry 37, 3 (2018): 846-853. [PubMed Link] | [ Full text ]
Fan, TW ; El-Amouri, SS ; Macedo, JKA ; Wang, QJ ; Song, H.; Cassel, T.; Lane, AN "Stable Isotope-Resolved Metabolomics Shows Metabolic Resistance to Anti-Cancer Selenite in 3D Spheroids versus 2D Cell Cultures." Metabolites 8, 3 (2018): [PubMed Link] | [ Full text ]
Deng, P.; Higashi, RM ; Lane, AN ; Bruntz, RC ; Sun, RC ; Raju, MVR ; Nantz, MH ; Qi, Z.; Fan, TW "Correction: Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS." The Analyst 143, 4 (2018): 999. [PubMed Link] | [ Full text ]
Fan, TWM ; Zhang, X.; Wang, C.; Yang, Y.; Kang, WY ; Arnold, S.; Higashi, RM ; Liu, J.; Lane, AN "Exosomal lipids for classifying early and late stage non-small cell lung cancer." Analytica chimica acta 1037, (2018): 256-264. [PubMed Link] | [ Full text ]
Lane, AN ; Tan, J.; Wang, Y.; Yan, J.; Higashi, RM ; Fan, TW "Probing the metabolic phenotype of breast cancer cells by multiple tracer stable isotope resolved metabolomics." Metabolic engineering 43, Pt B (2017): 125-136. [PubMed Link] | [ Full text ]
Zhao, J.; Li, J.; Fan, TWM ; Hou, SX "Glycolytic reprogramming through PCK2 regulates tumor initiation of prostate cancer cells." Oncotarget 8, 48 (2017): 83602-83618. [PubMed Link] | [ Full text ]
Sun, RC ; Fan, TW ; Deng, P.; Higashi, RM ; Lane, AN ; Le, AT ; Scott, TL ; Sun, Q.; Warmoes, MO ; Yang, Y. "Noninvasive liquid diet delivery of stable isotopes into mouse models for deep metabolic network tracing." Nature communications 8, 1 (2017): 1646. [PubMed Link] | [ Full text ]
Wang, Q.; Zhou, Y.; Rychahou, P.; Fan, TW ; Lane, AN ; Weiss, HL ; Evers, BM "Ketogenesis contributes to intestinal cell differentiation." Cell death and differentiation 24, 3 (2017): 458-468. [PubMed Link] | [ Full text ]
Zhao, J.; Li, J.; Fan, TWM ; Hou, SX "Glycolytic reprogramming through PCK2 regulates tumor initiation of prostate cancer cells." Oncotarget (2017): [PubMed Link] | [ Full text ]
Bruntz, RC ; Lane, AN ; Higashi, RM ; Fan, TW "Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM)." The Journal of biological chemistry 292, 28 (2017): 11601-11609. [PubMed Link] | [ Full text ]
Yang, Y.; Fan, TW ; Lane, AN ; Higashi, RM "Chloroformate derivatization for tracing the fate of Amino acids in cells and tissues by multiple stable isotope resolved metabolomics (mSIRM)." Analytica chimica acta 976, (2017): 63-73. [PubMed Link] | [ Full text ]
Deng, P.; Higashi, RM ; Lane, AN ; Bruntz, RC ; Sun, RC ; Ramakrishnam Raju, MV ; Nantz, MH ; Qi, Z.; Fan, TW "Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS." The Analyst 143, 1 (2017): 311-322. [PubMed Link] | [ Full text ]
Lane, AN ; Fan, TW "NMR-based Stable Isotope Resolved Metabolomics in systems biochemistry." Archives of biochemistry and biophysics 628, (2017): 123-131. [PubMed Link] | [ Full text ]
Li, J.; Song, J.; Zaytseva, YY ; Liu, Y.; Rychahou, P.; Jiang, K.; Starr, ME ; Kim, JT ; Harris, JW ; Yiannikouris, FB ; Katz, WS ; Nilsson, PM ; Orho-Melander, M.; Chen, J.; Zhu, H.; Fahrenholz, T.; Higashi, RM ; Gao, T.; Morris, AJ ; Cassis, LA ; Fan, TW ; Weiss, HL ; Dobner, PR ; Melander, O.; Jia, J.; Evers, BM "An obligatory role for neurotensin in high-fat-diet-induced obesity." Nature 533, 7603 (2016): 411-5. [PubMed Link] | [ Full text ]
Liu, M.; Luo, F.; Ding, C.; Albeituni, S.; Hu, X.; Ma, Y.; Cai, Y.; McNally, L.; Sanders, MA ; Jain, D.; Kloecker, G.; Bousamra M, 2nd ; Zhang, HG ; Higashi, RM ; Lane, AN ; Fan, TW ; Yan, J. "Correction: Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype." Journal of immunology (Baltimore, Md. : 1950) 196, 9 (2016): 3968. [PubMed Link] | [ Full text ]
Lane, AN ; Higashi, RM ; Fan, TW "Preclinical models for interrogating drug action in human cancers using Stable Isotope Resolved Metabolomics (SIRM)." Metabolomics : Official journal of the Metabolomic Society 12, 7 (2016): [PubMed Link] |
Fan, TW ; Warmoes, MO ; Sun, Q.; Song, H.; Turchan-Cholewo, J.; Martin, JT ; Mahan, A.; Higashi, RM ; Lane, AN "Distinctly perturbed metabolic networks underlie differential tumor tissue damages induced by immune modulator β-glucan in a two-case ex vivo non-small-cell lung cancer study." Cold Spring Harbor molecular case studies 2, 4 (2016): a000893. [PubMed Link] | [ Full text ]
Saxena, N.; Maio, N.; Crooks, DR ; Ricketts, CJ ; Yang, Y.; Wei, MH ; Fan, TW ; Lane, AN ; Sourbier, C.; Singh, A.; Killian, JK ; Meltzer, PS ; Vocke, CD ; Rouault, TA ; Linehan, WM "SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery." Journal of the National Cancer Institute 108, 1 (2016): [PubMed Link] | [ Full text ]
Fan, TW ; Lane, AN ; Higashi, RM "Stable Isotope Resolved Metabolomics Studies in Ex Vivo TIssue Slices." Bio-protocol 6, 3 (2016): [PubMed Link] |
Fan, TW ; Lane, AN "Applications of NMR spectroscopy to systems biochemistry." Progress in nuclear magnetic resonance spectroscopy 92-93, (2016): 18-53. [PubMed Link] | [ Full text ]
Saxena, N.; Maio, N.; Crooks, DR ; Ricketts, CJ ; Yang, Y.; Wei, MH ; Fan, TW ; Lane, AN ; Sourbier, C.; Singh, A.; Killian, JK ; Meltzer, PS ; Vocke, CD ; Rouault, TA ; Linehan, WM "SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery." Journal of the National Cancer Institute 108, 1 (2015): [PubMed Link] |
Lane, AN ; Yan, J.; Fan, TW "13C Tracer Studies of Metabolism in Mouse Tumor Xenografts." Bio-protocol 5, 22 (2015): [PubMed Link] |
Liu, M.; Luo, F.; Ding, C.; Albeituni, S.; Hu, X.; Ma, Y.; Cai, Y.; McNally, L.; Sanders, MA ; Jain, D.; Kloecker, G.; Bousamra M, 2nd ; Zhang, HG ; Higashi, RM ; Lane, AN ; Fan, TW ; Yan, J. "Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype." Journal of immunology (Baltimore, Md. : 1950) 195, 10 (2015): 5055-65. [PubMed Link] | [ Full text ]
Lane, AN ; Arumugam, S.; Lorkiewicz, PK ; Higashi, RM ; Laulhé, S.; Nantz, MH ; Moseley, HN ; Fan, TW "Chemoselective detection and discrimination of carbonyl-containing compounds in metabolite mixtures by 1H-detected 15N nuclear magnetic resonance." Magnetic resonance in chemistry : MRC 53, 5 (2015): 337-43. [PubMed Link] | [ Full text ]
Lane, AN ; Fan, TW "Regulation of mammalian nucleotide metabolism and biosynthesis." Nucleic acids research 43, 4 (2015): 2466-85. [PubMed Link] | [ Full text ]
Sellers, K.; Fox, MP ; Bousamra M, 2nd ; Slone, SP ; Higashi, RM ; Miller, DM ; Wang, Y.; Yan, J.; Yuneva, MO ; Deshpande, R.; Lane, AN ; Fan, TW "Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation." The Journal of clinical investigation 125, 2 (2015): 687-98. [PubMed Link] | [ Full text ]
Tarrado-Castellarnau, M.; Cortés, R.; Zanuy, M.; Tarragó-Celada, J.; Polat, IH ; Hill, R.; Fan, TW ; Link, W.; Cascante, M. "Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition." Pharmacological research 102, (2015): 218-34. [PubMed Link] | [ Full text ]
Xie, H.; Hanai, J.; Ren, JG ; Kats, L.; Burgess, K.; Bhargava, P.; Signoretti, S.; Billiard, J.; Duffy, KJ ; Grant, A.; Wang, X.; Lorkiewicz, PK ; Schatzman, S.; Bousamra M, 2nd ; Lane, AN ; Higashi, RM ; Fan, TW ; Pandolfi, PP ; Sukhatme, VP ; Seth, P. "Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells." Cell metabolism 19, 5 (2014): 795-809. [PubMed Link] | [ Full text ]
Ren, JG ; Seth, P.; Clish, CB ; Lorkiewicz, PK ; Higashi, RM ; Lane, AN ; Fan, TW ; Sukhatme, VP "Knockdown of malic enzyme 2 suppresses lung tumor growth, induces differentiation and impacts PI3K/AKT signaling." Scientific reports 4, (2014): 5414. [PubMed Link] | [ Full text ]
Gori, SS ; Lorkiewicz, P.; Ehringer, DS ; Belshoff, AC ; Higashi, RM ; Fan, TW ; Nantz, MH "Profiling thiol metabolites and quantification of cellular glutathione using FT-ICR-MS spectrometry." Analytical and bioanalytical chemistry 406, 18 (2014): 4371-9. [PubMed Link] | [ Full text ]
Guin, S.; Pollard, C.; Ru, Y.; Ritterson Lew, C.; Duex, JE ; Dancik, G.; Owens, C.; Spencer, A.; Knight, S.; Holemon, H.; Gupta, S.; Hansel, D.; Hellerstein, M.; Lorkiewicz, P.; Lane, AN ; Fan, TW ; Theodorescu, D. "Role in tumor growth of a glycogen debranching enzyme lost in glycogen storage disease." Journal of the National Cancer Institute 106, 5 (2014): [PubMed Link] | [ Full text ]
Higashi, RM ; Fan, TW ; Lorkiewicz, PK ; Moseley, HN ; Lane, AN "Stable isotope-labeled tracers for metabolic pathway elucidation by GC-MS and FT-MS." Methods in molecular biology (Clifton, N.J.) 1198, (2014): 147-67. [PubMed Link] | [ Full text ]
Mitchell, JM ; Fan, TW ; Lane, AN ; Moseley, HN "Development and in silico evaluation of large-scale metabolite identification methods using functional group detection for metabolomics." Frontiers in genetics 5, (2014): 237. [PubMed Link] | [ Full text ]
Dong, C.; Yuan, T.; Wu, Y.; Wang, Y.; Fan, TW ; Miriyala, S.; Lin, Y.; Yao, J.; Shi, J.; Kang, T.; Lorkiewicz, P.; St Clair, D.; Hung, MC ; Evers, BM ; Zhou, BP "Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer." Cancer cell 23, 3 (2013): 316-31. [PubMed Link] | [ Full text ]
Yang, Y.; Lane, AN ; Ricketts, CJ ; Sourbier, C.; Wei, MH ; Shuch, B.; Pike, L.; Wu, M.; Rouault, TA ; Boros, LG ; Fan, TW ; Linehan, WM "Metabolic reprogramming for producing energy and reducing power in fumarate hydratase null cells from hereditary leiomyomatosis renal cell carcinoma." PloS one 8, 8 (2013): e72179. [PubMed Link] | [ Full text ]
Muenyi, CS ; Pinhas, AR ; Fan, TW ; Brock, GN ; Helm, CW ; States, JC "Sodium arsenite ± hyperthermia sensitizes p53-expressing human ovarian cancer cells to cisplatin by modulating platinum-DNA damage responses." Toxicological sciences : an official journal of the Society of Toxicology 127, 1 (2012): 139-49. [PubMed Link] | [ Full text ]
Fan, TW ; Lorkiewicz, PK ; Sellers, K.; Moseley, HN ; Higashi, RM ; Lane, AN "Stable isotope-resolved metabolomics and applications for drug development." Pharmacology & therapeutics 133, 3 (2012): 366-91. [PubMed Link] | [ Full text ]
Liu, W.; Le, A.; Hancock, C.; Lane, AN ; Dang, CV ; Fan, TW ; Phang, JM "Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC." Proceedings of the National Academy of Sciences of the United States of America 109, 23 (2012): 8983-8. [PubMed Link] | [ Full text ]
Fan, TW ; Tan, J.; McKinney, MM ; Lane, AN "Stable Isotope Resolved Metabolomics Analysis of Ribonucleotide and RNA Metabolism in Human Lung Cancer Cells." Metabolomics : Official journal of the Metabolomic Society 8, 3 (2012): 517-527. [PubMed Link] |
Le, A.; Lane, AN ; Hamaker, M.; Bose, S.; Gouw, A.; Barbi, J.; Tsukamoto, T.; Rojas, CJ ; Slusher, BS ; Zhang, H.; Zimmerman, LJ ; Liebler, DC ; Slebos, RJ ; Lorkiewicz, PK ; Higashi, RM ; Fan, TW ; Dang, CV "Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells." Cell metabolism 15, 1 (2012): 110-21. [PubMed Link] | [ Full text ]
Yuneva, MO ; Fan, TW ; Allen, TD ; Higashi, RM ; Ferraris, DV ; Tsukamoto, T.; Matés, JM ; Alonso, FJ ; Wang, C.; Seo, Y.; Chen, X.; Bishop, JM "The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type." Cell metabolism 15, 2 (2012): 157-70. [PubMed Link] | [ Full text ]
Mattingly, SJ ; Xu, T.; Nantz, MH ; Higashi, RM ; Fan, TW "A Carbonyl Capture Approach for Profiling Oxidized Metabolites in Cell Extracts." Metabolomics : Official journal of the Metabolomic Society 8, 6 (2012): 989-996. [PubMed Link] |
Lorkiewicz, P.; Higashi, RM ; Lane, AN ; Fan, TW "High information throughput analysis of nucleotides and their isotopically enriched isotopologues by direct-infusion FTICR-MS." Metabolomics : Official journal of the Metabolomic Society 8, 5 (2012): 930-939. [PubMed Link] |
Gracey, AY ; Lee, TH ; Higashi, RM ; Fan, T. "Hypoxia-induced mobilization of stored triglycerides in the euryoxic goby Gillichthys mirabilis." The Journal of experimental biology 214, Pt 18 (2011): 3005-12. [PubMed Link] | [ Full text ]
Moseley, HN ; Lane, AN ; Belshoff, AC ; Higashi, RM ; Fan, TW "A novel deconvolution method for modeling UDP-N-acetyl-D-glucosamine biosynthetic pathways based on (13)C mass isotopologue profiles under non-steady-state conditions." BMC biology 9, (2011): 37. [PubMed Link] | [ Full text ]
Lane, AN ; Fan, TW ; Bousamra M, 2nd ; Higashi, RM ; Yan, J.; Miller, DM "Stable isotope-resolved metabolomics (SIRM) in cancer research with clinical application to nonsmall cell lung cancer." Omics : a journal of integrative biology 15, 3 (2011): 173-82. [PubMed Link] | [ Full text ]
Muenyi, CS ; States, VA ; Masters, JH ; Fan, TW ; Helm, CW ; States, JC "Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal chemotherapy (HIPEC)." Journal of ovarian research 4, (2011): 9. [PubMed Link] | [ Full text ]
Fan, TW ; Lane, AN ; Higashi, RM ; Yan, J. "Stable isotope resolved metabolomics of lung cancer in a SCID mouse model." Metabolomics : Official journal of the Metabolomic Society 7, 2 (2011): 257-269. [PubMed Link] |
Fan, TW ; Lane, AN "NMR-based stable isotope resolved metabolomics in systems biochemistry." Journal of biomolecular NMR 49, 3-4 (2011): 267-80. [PubMed Link] | [ Full text ]
Selivanov, VA ; Vizán, P.; Mollinedo, F.; Fan, TW ; Lee, PW ; Cascante, M. "Edelfosine-induced metabolic changes in cancer cells that precede the overproduction of reactive oxygen species and apoptosis." BMC systems biology 4, (2010): 135. [PubMed Link] | [ Full text ]
Fan, TW ; Yuan, P.; Lane, AN ; Higashi, RM ; Wang, Y.; Hamidi, AB ; Zhou, R.; Guitart, X.; Chen, G.; Manji, HK ; Kaddurah-Daouk, R. "Stable isotope-resolved metabolomic analysis of lithium effects on glial-neuronal metabolism and interactions." Metabolomics : Official journal of the Metabolomic Society 6, 2 (2010): 165-179. [PubMed Link] |
Lane, AN ; Fan, TW ; Xie, Z.; Moseley, HN ; Higashi, RM "Isotopomer analysis of lipid biosynthesis by high resolution mass spectrometry and NMR." Analytica chimica acta 651, 2 (2009): 201-8. [PubMed Link] | [ Full text ]
Fan, TW ; Lane, AN ; Higashi, RM ; Farag, MA ; Gao, H.; Bousamra, M.; Miller, DM "Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM)." Molecular cancer 8, (2009): 41. [PubMed Link] | [ Full text ]
Lane, AN ; Fan, TW ; Higashi, RM ; Tan, J.; Bousamra, M.; Miller, DM "Prospects for clinical cancer metabolomics using stable isotope tracers." Experimental and molecular pathology 86, 3 (2009): 165-73. [PubMed Link] | [ Full text ]
Fan, TW ; Lane, AN ; Higashi, RM ; Bousamra M, 2nd ; Kloecker, G.; Miller, DM "Metabolic profiling identifies lung tumor responsiveness to erlotinib." Experimental and molecular pathology 87, 1 (2009): 83-6. [PubMed Link] | [ Full text ]
Fan, TW ; Kucia, M.; Jankowski, K.; Higashi, RM ; Ratajczak, J.; Ratajczak, MZ ; Lane, AN "Rhabdomyosarcoma cells show an energy producing anabolic metabolic phenotype compared with primary myocytes." Molecular cancer 7, (2008): 79. [PubMed Link] | [ Full text ]
McNeely, SC ; Belshoff, AC ; Taylor, BF ; Fan, TW ; McCabe MJ, Jr ; Pinhas, AR ; States, JC "Sensitivity to sodium arsenite in human melanoma cells depends upon susceptibility to arsenite-induced mitotic arrest." Toxicology and applied pharmacology 229, 2 (2008): 252-61. [PubMed Link] | [ Full text ]
Lane, AN ; Fan, TW ; Higashi, RM "Stable isotope-assisted metabolomics in cancer research." IUBMB life 60, 2 (2008): 124-9. [PubMed Link] | [ Full text ]
Fan, T.; Elgourt, T. "Pain management pharmacy service in a community hospital." American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 65, 16 (2008): 1560-5. [PubMed Link] | [ Full text ]
Lane, AN ; Fan, TW ; Higashi, RM "Isotopomer-based metabolomic analysis by NMR and mass spectrometry." Methods in cell biology 84, (2008): 541-88. [PubMed Link] | [ Full text ]
Sumner, LW ; Amberg, A.; Barrett, D.; Beale, MH ; Beger, R.; Daykin, CA ; Fan, TW ; Fiehn, O.; Goodacre, R.; Griffin, JL ; Hankemeier, T.; Hardy, N.; Harnly, J.; Higashi, R.; Kopka, J.; Lane, AN ; Lindon, JC ; Marriott, P.; Nicholls, AW ; Reily, MD ; Thaden, JJ ; Viant, MR "Proposed minimum reporting standards for chemical analysis Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI)." Metabolomics : Official journal of the Metabolomic Society 3, 3 (2007): 211-221. [PubMed Link] |
Podrabsky, JE ; Lopez, JP ; Fan, TW ; Higashi, R.; Somero, GN "Extreme anoxia tolerance in embryos of the annual killifish Austrofundulus limnaeus: insights from a metabolomics analysis." The Journal of experimental biology 210, Pt 13 (2007): 2253-66. [PubMed Link] | [ Full text ]
MSI Board, Members. ; Sansone, SA ; Fan, T.; Goodacre, R.; Griffin, JL ; Hardy, NW ; Kaddurah-Daouk, R.; Kristal, BS ; Lindon, J.; Mendes, P.; Morrison, N.; Nikolau, B.; Robertson, D.; Sumner, LW ; Taylor, C.; Werf, M.; Ommen, B.; Fiehn, O. "The metabolomics standards initiative." Nature biotechnology 25, 8 (2007): 846-8. [PubMed Link] | [ Full text ]
Rose, WL ; Nisbet, RM ; Green, PG ; Norris, S.; Fan, T.; Smith, EH ; Cherr, GN ; Anderson, SL "Using an integrated approach to link biomarker responses and physiological stress to growth impairment of cadmium-exposed larval topsmelt." Aquatic toxicology (Amsterdam, Netherlands) 80, 3 (2006): 298-308. [PubMed Link] | [ Full text ]
Fan, TW ; Higashi, RM ; Lane, AN "Integrating metabolomics and transcriptomics for probing SE anticancer mechanisms." Drug metabolism reviews 38, 4 (2006): 707-32. [PubMed Link] | [ Full text ]
Teh, SJ ; Deng, X.; Deng, DF ; Teh, FC ; Hung, SS ; Fan, TW ; Liu, J.; Higashi, RM "Chronic effects of dietary selenium on juvenile Sacramento splittail (Pogonichthys macrolepidotus)." Environmental science & technology 38, 22 (2004): 6085-93. [PubMed Link] | [ Full text ]
Fan, TW ; Lane, AN ; Higashi, RM "An electrophoretic profiling method for thiol-rich phytochelatins and metallothioneins." Phytochemical analysis : PCA 15, 3 (2004): 175-83. [PubMed Link] | [ Full text ]
Fan, TW ; Lane, AN ; Higashi, RM "The promise of metabolomics in cancer molecular therapeutics." Current opinion in molecular therapeutics 6, 6 (2004): 584-92. [PubMed Link] |
Ramos, A.; Lane, AN ; Hollingworth, D.; Fan, TW "Secondary structure and stability of the selenocysteine insertion sequences (SECIS) for human thioredoxin reductase and glutathione peroxidase." Nucleic acids research 32, 5 (2004): 1746-55. [PubMed Link] | [ Full text ]
Fan, TW ; Teh, SJ ; Hinton, DE ; Higashi, RM "Selenium biotransformations into proteinaceous forms by foodweb organisms of selenium-laden drainage waters in California." Aquatic toxicology (Amsterdam, Netherlands) 57, 1-2 (2002): 65-84. [PubMed Link] | [ Full text ]