Whei-Mei Teresa Fan | Toxicology and Cancer Biology

Whei-Mei Teresa Fan

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Publications

531 BioPharm Complex

Position(s):

Professor, Edith D. Gardner Chair in Cancer Research

Affiliation(s):

Toxicology and Cancer Biology

PubMed Publications:

Reyes-Caballero, H ; Rao, X.; Sun, Q.; Warmoes, MO ; Lin, P.; Sussan, TE ; Park, B.; Fan, TW ; Maiseyeu, A.; Rajagopalan, S.; Girnun, GD ; Biswal, S. "Author Correction: Air pollution-derived particulate matter dysregulates hepatic Krebs cycle, glucose and lipid metabolism in mice." Scientific reports 10, 1 (2020): 5082. [PubMed Link] | [ Full text ]
Lane, AN ; Higashi, RM ; Fan, TW "Metabolic reprogramming in tumors: Contributions of the tumor microenvironment." Genes & diseases 7, 2 (2020): 185-198. [PubMed Link] | [ Full text ]
Huang, Z.; Lane, AN ; Fan, TW ; Higashi, RM ; Weiss, HL ; Yin, X.; Wang, C. "Differential Abundance Analysis with Bayes Shrinkage Estimation of Variance (DASEV) for Zero-Inflated Proteomic and Metabolomic Data." Scientific reports 10, 1 (2020): 876. [PubMed Link] | [ Full text ]
Palmieri, EM ; Gonzalez-Cotto, M ; Baseler, WA ; Davies, LC ; Ghesquière, B ; Maio, N.; Rice, CM ; Rouault, TA ; Cassel, T.; Higashi, RM ; Lane, AN ; Fan, TW ; Wink, DA ; McVicar, DW "Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase." Nature communications 11, 1 (2020): 698. [PubMed Link] | [ Full text ]
Xiao, GG ; Zhang, Z.; Lu, B.; Wang, H.; Fan, TW ; Boros, LG ; Gao, P.; Pan, Y.; Go, VLW "Proceedings of the 3rd International Conference for Cancer Metabolism and Therapy, October 12-14, 2018, Shanghai, China." Pancreas 49, 2 (2020): 149-157. [PubMed Link] | [ Full text ]
Sengupta, D.; Cassel, T.; Teng, KY ; Aljuhani, M ; Chowdhary, VK ; Hu, P.; Zhang, X.; Fan, TW ; Ghoshal, K "Regulation of hepatic glutamine metabolism by miR-122." Molecular metabolism 34, (2020): 174-186. [PubMed Link] | [ Full text ]
Selivanov, VA ; Marin, S ; Tarragó-Celada, J.; Lane, AN ; Higashi, RM ; Fan, TW ; de Atauri, P ; Cascante, M. "Software Supporting a Workflow of Quantitative Dynamic Flux Maps Estimation in Central Metabolism from SIRM Experimental Data." Methods in molecular biology (Clifton, N.J.) 2088, (2020): 271-298. [PubMed Link] | [ Full text ]
Fan, TWM ; Bruntz, RC ; Yang, Y.; Song, H.; Chernyavskaya, Y ; Deng, P.; Zhang, Y.; Shah, PP ; Beverly, LJ ; Qi, Z.; Mahan, AL ; Higashi, RM ; Dang, CV ; Lane, AN "De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues." The Journal of biological chemistry 294, 36 (2019): 13464-13477. [PubMed Link] | [ Full text ]
Li, Y.; Fan, TWM ; Lane, AN ; Kang, WY ; Arnold, SM ; Stromberg, AJ ; Wang, C.; Chen, L. "SDA: a semi-parametric differential abundance analysis method for metabolomics and proteomics data." BMC bioinformatics 20, 1 (2019): 501. [PubMed Link] | [ Full text ]
Wen, YA ; Xiong, X.; Scott, T.; Li, AT ; Wang, C.; Weiss, HL ; Tan, L.; Bradford, E ; Fan, TWM ; Chandel, NS ; Barrett, TA ; Gao, T. "The mitochondrial retrograde signaling regulates Wnt signaling to promote tumorigenesis in colon cancer." Cell death and differentiation 26, 10 (2019): 1955-1969. [PubMed Link] | [ Full text ]
Kang, WY ; Thompson, PT ; El-Amouri, SS ; Fan, TWM ; Lane, AN ; Higashi, RM "Improved segmented-scan spectral stitching for stable isotope resolved metabolomics (SIRM) by ultra-high-resolution Fourier transform mass spectrometry." Analytica chimica acta 1080, (2019): 104-115. [PubMed Link] | [ Full text ]
Reyes-Caballero, H ; Rao, X.; Sun, Q.; Warmoes, MO ; Lin, P.; Sussan, TE ; Park, B.; Fan, TW ; Maiseyeu, A.; Rajagopalan, S.; Girnun, GD ; Biswal, S. "Air pollution-derived particulate matter dysregulates hepatic Krebs cycle, glucose and lipid metabolism in mice." Scientific reports 9, 1 (2019): 17423. [PubMed Link] | [ Full text ]
Rao, TN ; Hansen, N ; Hilfiker, J ; Rai, S.; Majewska, JM ; Leković, D ; Gezer, D ; Andina, N ; Galli, S.; Cassel, T.; Geier, F ; Delezie, J ; Nienhold, R ; Hao-Shen, H ; Beisel, C ; Di Palma, S ; Dimeloe, S ; Trebicka, J ; Wolf, D.; Gassmann, M.; Fan, TW ; Lane, AN ; Handschin, C ; Dirnhofer, S ; Kröger, N ; Hess, C ; Radimerski, T ; Koschmieder, S.; Čokić, VP ; Skoda, RC "JAK2-mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms." Blood 134, 21 (2019): 1832-1846. [PubMed Link] | [ Full text ]
Bruntz, RC ; Belshoff, AC ; Zhang, Y.; Macedo, JKA ; Higashi, RM ; Lane, AN ; Fan, TW "Inhibition of Anaplerotic Glutaminolysis Underlies Selenite Toxicity in Human Lung Cancer." Proteomics 19, 21-22 (2019): e1800486. [PubMed Link] | [ Full text ]
Zhang, Y.; Zhang, X.; Lane, AN ; Fan, TW ; Liu, J. "Inferring Gene Regulatory Networks of Metabolic Enzymes Using Gradient Boosted Trees." IEEE journal of biomedical and health informatics (2019): [PubMed Link] | [ Full text ]
Sellers, K.; Allen, TD ; Bousamra M, 2nd ; Tan, J.; Méndez-Lucas, A.; Lin, W.; Bah, N ; Chernyavskaya, Y ; MacRae, JI ; Higashi, RM ; Lane, AN ; Fan, TW ; Yuneva, MO "Metabolic reprogramming and Notch activity distinguish between non-small cell lung cancer subtypes." British journal of cancer 121, 1 (2019): 51-64. [PubMed Link] | [ Full text ]
Kulkarni, RA ; Briney, CA ; Crooks, DR ; Bergholtz, SE ; Mushti, C ; Lockett, SJ ; Lane, AN ; Fan, TW ; Swenson, RE ; Linehan, Marston ; Meier, JL "Photoinducible Oncometabolite Detection." Chembiochem : a European journal of chemical biology 20, 3 (2019): 360-365. [PubMed Link] | [ Full text ]
Kishimoto, S ; , ; Crooks, DR ; Matsumoto, S.; Seki, T.; Oshima, N ; Merkle, H ; Lin, P.; Reed, G.; Chen, AP ; Ardenkjaer-Larsen, JH ; Munasinghe, J ; Saito, K.; Yamamoto, K.; Choyke, PL ; Mitchell, J.; Lane, AN ; Fan, TW ; Linehan, WM ; Krishna, MC "Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice." eLife 8, (2019): [PubMed Link] | [ Full text ]
Crooks, DR ; Fan, TW ; Linehan, WM "Metabolic Labeling of Cultured Mammalian Cells for Stable Isotope-Resolved Metabolomics: Practical Aspects of Tissue Culture and Sample Extraction." Methods in molecular biology (Clifton, N.J.) 1928, (2019): 1-27. [PubMed Link] | [ Full text ]
Lin, P.; Lane, AN ; Fan, TW "Stable Isotope-Resolved Metabolomics by NMR." Methods in molecular biology (Clifton, N.J.) 2037, (2019): 151-168. [PubMed Link] | [ Full text ]
Yang, Y.; Fan, TW ; Lane, AN ; Higashi, RM "Quantification of Isotopologues of Amino Acids by Multiplexed Stable Isotope-Resolved Metabolomics Using Ultrahigh-Resolution Mass Spectrometry Coupled with Direct Infusion." Methods in molecular biology (Clifton, N.J.) 2030, (2019): 57-68. [PubMed Link] | [ Full text ]
Mitchell, JM ; Flight, RM ; Wang, QJ ; Higashi, RM ; Fan, TW ; Lane, AN ; Moseley, HNB "New methods to identify high peak density artifacts in Fourier transform mass spectra and to mitigate their effects on high-throughput metabolomic data analysis." Metabolomics : Official journal of the Metabolomic Society 14, 10 (2018): 125. [PubMed Link] |
Lian, G ; , ; Wang, T.; Wu, R.; Chen, X.; Liu, L.; Shen, Y.; Yang, M.; Yang, J.; Chen, Y.; Vasiliou, V ; Cassel, TA ; Green, DR ; Liu, Y.; Fan, TW ; Wang, R. "Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation." eLife 7, (2018): [PubMed Link] | [ Full text ]
Crooks, DR ; Maio, N.; Lane, AN ; Jarnik, M.; Higashi, RM ; Haller, RG ; Yang, Y.; Fan, TW ; Linehan, WM ; Rouault, TA "Acute loss of iron-sulfur clusters results in metabolic reprogramming and generation of lipid droplets in mammalian cells." The Journal of biological chemistry 293, 21 (2018): 8297-8311. [PubMed Link] | [ Full text ]
Zaytseva, YY ; Rychahou, PG ; Le, AT ; Scott, TL ; Flight, RM ; Kim, JT ; Harris, J.; Liu, J.; Wang, C.; Morris, AJ ; Sivakumaran, TA ; Fan, T.; Moseley, H.; Gao, T.; Lee, EY ; Weiss, HL ; Heuer, TS ; Kemble, G.; Evers, M. "Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer." Oncotarget 9, 37 (2018): 24787-24800. [PubMed Link] | [ Full text ]
Kuperman, RG ; Checkai, RT ; Simini, M.; Phillips, CT ; Higashi, RM ; Fan, TW ; Sappington, K. "Selenium toxicity to survival and reproduction of Collembola and Enchytraeids in a sandy loam soil." Environmental toxicology and chemistry 37, 3 (2018): 846-853. [PubMed Link] | [ Full text ]
Fan, TW ; El-Amouri, SS ; Macedo, JKA ; Wang, QJ ; Song, H.; Cassel, T.; Lane, AN "Stable Isotope-Resolved Metabolomics Shows Metabolic Resistance to Anti-Cancer Selenite in 3D Spheroids versus 2D Cell Cultures." Metabolites 8, 3 (2018): [PubMed Link] | [ Full text ]
Deng, P.; Higashi, RM ; Lane, AN ; Bruntz, RC ; Sun, RC ; Raju, MVR ; Nantz, MH ; Qi, Z.; Fan, TW "Correction: Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS." The Analyst 143, 4 (2018): 999. [PubMed Link] | [ Full text ]
Fan, TWM ; Zhang, X.; Wang, C.; Yang, Y.; Kang, WY ; Arnold, S.; Higashi, RM ; Liu, J.; Lane, AN "Exosomal lipids for classifying early and late stage non-small cell lung cancer." Analytica chimica acta 1037, (2018): 256-264. [PubMed Link] | [ Full text ]
Lane, AN ; Tan, J.; Wang, Y.; Yan, J.; Higashi, RM ; Fan, TW "Probing the metabolic phenotype of breast cancer cells by multiple tracer stable isotope resolved metabolomics." Metabolic engineering 43, Pt B (2017): 125-136. [PubMed Link] | [ Full text ]
Zhao, J.; Li, J.; Fan, TWM ; Hou, SX "Glycolytic reprogramming through PCK2 regulates tumor initiation of prostate cancer cells." Oncotarget 8, 48 (2017): 83602-83618. [PubMed Link] | [ Full text ]
Sun, RC ; Fan, TW ; Deng, P.; Higashi, RM ; Lane, AN ; Le, AT ; Scott, TL ; Sun, Q.; Warmoes, MO ; Yang, Y. "Noninvasive liquid diet delivery of stable isotopes into mouse models for deep metabolic network tracing." Nature communications 8, 1 (2017): 1646. [PubMed Link] | [ Full text ]
Wang, Q.; Zhou, Y.; Rychahou, P.; Fan, TW ; Lane, AN ; Weiss, HL ; Evers, BM "Ketogenesis contributes to intestinal cell differentiation." Cell death and differentiation 24, 3 (2017): 458-468. [PubMed Link] | [ Full text ]
Zhao, J.; Li, J.; Fan, TWM ; Hou, SX "Glycolytic reprogramming through PCK2 regulates tumor initiation of prostate cancer cells." Oncotarget (2017): [PubMed Link] | [ Full text ]
Bruntz, RC ; Lane, AN ; Higashi, RM ; Fan, TW "Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM)." The Journal of biological chemistry 292, 28 (2017): 11601-11609. [PubMed Link] | [ Full text ]
Yang, Y.; Fan, TW ; Lane, AN ; Higashi, RM "Chloroformate derivatization for tracing the fate of Amino acids in cells and tissues by multiple stable isotope resolved metabolomics (mSIRM)." Analytica chimica acta 976, (2017): 63-73. [PubMed Link] | [ Full text ]
Deng, P.; Higashi, RM ; Lane, AN ; Bruntz, RC ; Sun, RC ; Ramakrishnam Raju, MV ; Nantz, MH ; Qi, Z.; Fan, TW "Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS." The Analyst 143, 1 (2017): 311-322. [PubMed Link] | [ Full text ]
Lane, AN ; Fan, TW "NMR-based Stable Isotope Resolved Metabolomics in systems biochemistry." Archives of biochemistry and biophysics 628, (2017): 123-131. [PubMed Link] | [ Full text ]
Li, J.; Song, J.; Zaytseva, YY ; Liu, Y.; Rychahou, P.; Jiang, K.; Starr, ME ; Kim, JT ; Harris, JW ; Yiannikouris, FB ; Katz, WS ; Nilsson, PM ; Orho-Melander, M.; Chen, J.; Zhu, H.; Fahrenholz, T.; Higashi, RM ; Gao, T.; Morris, AJ ; Cassis, LA ; Fan, TW ; Weiss, HL ; Dobner, PR ; Melander, O.; Jia, J.; Evers, BM "An obligatory role for neurotensin in high-fat-diet-induced obesity." Nature 533, 7603 (2016): 411-5. [PubMed Link] | [ Full text ]
Liu, M.; Luo, F.; Ding, C.; Albeituni, S.; Hu, X.; Ma, Y.; Cai, Y.; McNally, L.; Sanders, MA ; Jain, D.; Kloecker, G.; Bousamra M, 2nd ; Zhang, HG ; Higashi, RM ; Lane, AN ; Fan, TW ; Yan, J. "Correction: Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype." Journal of immunology (Baltimore, Md. : 1950) 196, 9 (2016): 3968. [PubMed Link] | [ Full text ]
Lane, AN ; Higashi, RM ; Fan, TW "Preclinical models for interrogating drug action in human cancers using Stable Isotope Resolved Metabolomics (SIRM)." Metabolomics : Official journal of the Metabolomic Society 12, 7 (2016): [PubMed Link] |
Fan, TW ; Warmoes, MO ; Sun, Q.; Song, H.; Turchan-Cholewo, J.; Martin, JT ; Mahan, A.; Higashi, RM ; Lane, AN "Distinctly perturbed metabolic networks underlie differential tumor tissue damages induced by immune modulator β-glucan in a two-case ex vivo non-small-cell lung cancer study." Cold Spring Harbor molecular case studies 2, 4 (2016): a000893. [PubMed Link] | [ Full text ]
Saxena, N.; Maio, N.; Crooks, DR ; Ricketts, CJ ; Yang, Y.; Wei, MH ; Fan, TW ; Lane, AN ; Sourbier, C.; Singh, A.; Killian, JK ; Meltzer, PS ; Vocke, CD ; Rouault, TA ; Linehan, WM "SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery." Journal of the National Cancer Institute 108, 1 (2016): [PubMed Link] | [ Full text ]
Fan, TW ; Lane, AN ; Higashi, RM "Stable Isotope Resolved Metabolomics Studies in Ex Vivo TIssue Slices." Bio-protocol 6, 3 (2016): [PubMed Link] |
Fan, TW ; Lane, AN "Applications of NMR spectroscopy to systems biochemistry." Progress in nuclear magnetic resonance spectroscopy 92-93, (2016): 18-53. [PubMed Link] | [ Full text ]
Saxena, N.; Maio, N.; Crooks, DR ; Ricketts, CJ ; Yang, Y.; Wei, MH ; Fan, TW ; Lane, AN ; Sourbier, C.; Singh, A.; Killian, JK ; Meltzer, PS ; Vocke, CD ; Rouault, TA ; Linehan, WM "SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery." Journal of the National Cancer Institute 108, 1 (2015): [PubMed Link] |
Lane, AN ; Yan, J.; Fan, TW "13C Tracer Studies of Metabolism in Mouse Tumor Xenografts." Bio-protocol 5, 22 (2015): [PubMed Link] |
Liu, M.; Luo, F.; Ding, C.; Albeituni, S.; Hu, X.; Ma, Y.; Cai, Y.; McNally, L.; Sanders, MA ; Jain, D.; Kloecker, G.; Bousamra M, 2nd ; Zhang, HG ; Higashi, RM ; Lane, AN ; Fan, TW ; Yan, J. "Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype." Journal of immunology (Baltimore, Md. : 1950) 195, 10 (2015): 5055-65. [PubMed Link] | [ Full text ]
Lane, AN ; Arumugam, S.; Lorkiewicz, PK ; Higashi, RM ; Laulhé, S.; Nantz, MH ; Moseley, HN ; Fan, TW "Chemoselective detection and discrimination of carbonyl-containing compounds in metabolite mixtures by 1H-detected 15N nuclear magnetic resonance." Magnetic resonance in chemistry : MRC 53, 5 (2015): 337-43. [PubMed Link] | [ Full text ]
Lane, AN ; Fan, TW "Regulation of mammalian nucleotide metabolism and biosynthesis." Nucleic acids research 43, 4 (2015): 2466-85. [PubMed Link] | [ Full text ]
Sellers, K.; Fox, MP ; Bousamra M, 2nd ; Slone, SP ; Higashi, RM ; Miller, DM ; Wang, Y.; Yan, J.; Yuneva, MO ; Deshpande, R.; Lane, AN ; Fan, TW "Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation." The Journal of clinical investigation 125, 2 (2015): 687-98. [PubMed Link] | [ Full text ]
Tarrado-Castellarnau, M.; Cortés, R.; Zanuy, M.; Tarragó-Celada, J.; Polat, IH ; Hill, R.; Fan, TW ; Link, W.; Cascante, M. "Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition." Pharmacological research 102, (2015): 218-34. [PubMed Link] | [ Full text ]
Xie, H.; Hanai, J.; Ren, JG ; Kats, L.; Burgess, K.; Bhargava, P.; Signoretti, S.; Billiard, J.; Duffy, KJ ; Grant, A.; Wang, X.; Lorkiewicz, PK ; Schatzman, S.; Bousamra M, 2nd ; Lane, AN ; Higashi, RM ; Fan, TW ; Pandolfi, PP ; Sukhatme, VP ; Seth, P. "Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells." Cell metabolism 19, 5 (2014): 795-809. [PubMed Link] | [ Full text ]
Ren, JG ; Seth, P.; Clish, CB ; Lorkiewicz, PK ; Higashi, RM ; Lane, AN ; Fan, TW ; Sukhatme, VP "Knockdown of malic enzyme 2 suppresses lung tumor growth, induces differentiation and impacts PI3K/AKT signaling." Scientific reports 4, (2014): 5414. [PubMed Link] | [ Full text ]
Gori, SS ; Lorkiewicz, P.; Ehringer, DS ; Belshoff, AC ; Higashi, RM ; Fan, TW ; Nantz, MH "Profiling thiol metabolites and quantification of cellular glutathione using FT-ICR-MS spectrometry." Analytical and bioanalytical chemistry 406, 18 (2014): 4371-9. [PubMed Link] | [ Full text ]
Guin, S.; Pollard, C.; Ru, Y.; Ritterson Lew, C.; Duex, JE ; Dancik, G.; Owens, C.; Spencer, A.; Knight, S.; Holemon, H.; Gupta, S.; Hansel, D.; Hellerstein, M.; Lorkiewicz, P.; Lane, AN ; Fan, TW ; Theodorescu, D. "Role in tumor growth of a glycogen debranching enzyme lost in glycogen storage disease." Journal of the National Cancer Institute 106, 5 (2014): [PubMed Link] | [ Full text ]
Higashi, RM ; Fan, TW ; Lorkiewicz, PK ; Moseley, HN ; Lane, AN "Stable isotope-labeled tracers for metabolic pathway elucidation by GC-MS and FT-MS." Methods in molecular biology (Clifton, N.J.) 1198, (2014): 147-67. [PubMed Link] | [ Full text ]
Mitchell, JM ; Fan, TW ; Lane, AN ; Moseley, HN "Development and in silico evaluation of large-scale metabolite identification methods using functional group detection for metabolomics." Frontiers in genetics 5, (2014): 237. [PubMed Link] | [ Full text ]
Dong, C.; Yuan, T.; Wu, Y.; Wang, Y.; Fan, TW ; Miriyala, S.; Lin, Y.; Yao, J.; Shi, J.; Kang, T.; Lorkiewicz, P.; St Clair, D.; Hung, MC ; Evers, BM ; Zhou, BP "Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer." Cancer cell 23, 3 (2013): 316-31. [PubMed Link] | [ Full text ]
Yang, Y.; Lane, AN ; Ricketts, CJ ; Sourbier, C.; Wei, MH ; Shuch, B.; Pike, L.; Wu, M.; Rouault, TA ; Boros, LG ; Fan, TW ; Linehan, WM "Metabolic reprogramming for producing energy and reducing power in fumarate hydratase null cells from hereditary leiomyomatosis renal cell carcinoma." PloS one 8, 8 (2013): e72179. [PubMed Link] | [ Full text ]
Muenyi, CS ; Pinhas, AR ; Fan, TW ; Brock, GN ; Helm, CW ; States, JC "Sodium arsenite ± hyperthermia sensitizes p53-expressing human ovarian cancer cells to cisplatin by modulating platinum-DNA damage responses." Toxicological sciences : an official journal of the Society of Toxicology 127, 1 (2012): 139-49. [PubMed Link] | [ Full text ]
Fan, TW ; Lorkiewicz, PK ; Sellers, K.; Moseley, HN ; Higashi, RM ; Lane, AN "Stable isotope-resolved metabolomics and applications for drug development." Pharmacology & therapeutics 133, 3 (2012): 366-91. [PubMed Link] | [ Full text ]
Liu, W.; Le, A.; Hancock, C.; Lane, AN ; Dang, CV ; Fan, TW ; Phang, JM "Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC." Proceedings of the National Academy of Sciences of the United States of America 109, 23 (2012): 8983-8. [PubMed Link] | [ Full text ]
Fan, TW ; Tan, J.; McKinney, MM ; Lane, AN "Stable Isotope Resolved Metabolomics Analysis of Ribonucleotide and RNA Metabolism in Human Lung Cancer Cells." Metabolomics : Official journal of the Metabolomic Society 8, 3 (2012): 517-527. [PubMed Link] |
Le, A.; Lane, AN ; Hamaker, M.; Bose, S.; Gouw, A.; Barbi, J.; Tsukamoto, T.; Rojas, CJ ; Slusher, BS ; Zhang, H.; Zimmerman, LJ ; Liebler, DC ; Slebos, RJ ; Lorkiewicz, PK ; Higashi, RM ; Fan, TW ; Dang, CV "Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells." Cell metabolism 15, 1 (2012): 110-21. [PubMed Link] | [ Full text ]
Yuneva, MO ; Fan, TW ; Allen, TD ; Higashi, RM ; Ferraris, DV ; Tsukamoto, T.; Matés, JM ; Alonso, FJ ; Wang, C.; Seo, Y.; Chen, X.; Bishop, JM "The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type." Cell metabolism 15, 2 (2012): 157-70. [PubMed Link] | [ Full text ]
Mattingly, SJ ; Xu, T.; Nantz, MH ; Higashi, RM ; Fan, TW "A Carbonyl Capture Approach for Profiling Oxidized Metabolites in Cell Extracts." Metabolomics : Official journal of the Metabolomic Society 8, 6 (2012): 989-996. [PubMed Link] |
Lorkiewicz, P.; Higashi, RM ; Lane, AN ; Fan, TW "High information throughput analysis of nucleotides and their isotopically enriched isotopologues by direct-infusion FTICR-MS." Metabolomics : Official journal of the Metabolomic Society 8, 5 (2012): 930-939. [PubMed Link] |
Gracey, AY ; Lee, TH ; Higashi, RM ; Fan, T. "Hypoxia-induced mobilization of stored triglycerides in the euryoxic goby Gillichthys mirabilis." The Journal of experimental biology 214, Pt 18 (2011): 3005-12. [PubMed Link] | [ Full text ]
Moseley, HN ; Lane, AN ; Belshoff, AC ; Higashi, RM ; Fan, TW "A novel deconvolution method for modeling UDP-N-acetyl-D-glucosamine biosynthetic pathways based on (13)C mass isotopologue profiles under non-steady-state conditions." BMC biology 9, (2011): 37. [PubMed Link] | [ Full text ]
Lane, AN ; Fan, TW ; Bousamra M, 2nd ; Higashi, RM ; Yan, J.; Miller, DM "Stable isotope-resolved metabolomics (SIRM) in cancer research with clinical application to nonsmall cell lung cancer." Omics : a journal of integrative biology 15, 3 (2011): 173-82. [PubMed Link] | [ Full text ]
Muenyi, CS ; States, VA ; Masters, JH ; Fan, TW ; Helm, CW ; States, JC "Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal chemotherapy (HIPEC)." Journal of ovarian research 4, (2011): 9. [PubMed Link] | [ Full text ]
Fan, TW ; Lane, AN ; Higashi, RM ; Yan, J. "Stable isotope resolved metabolomics of lung cancer in a SCID mouse model." Metabolomics : Official journal of the Metabolomic Society 7, 2 (2011): 257-269. [PubMed Link] |
Fan, TW ; Lane, AN "NMR-based stable isotope resolved metabolomics in systems biochemistry." Journal of biomolecular NMR 49, 3-4 (2011): 267-80. [PubMed Link] | [ Full text ]
Selivanov, VA ; Vizán, P.; Mollinedo, F.; Fan, TW ; Lee, PW ; Cascante, M. "Edelfosine-induced metabolic changes in cancer cells that precede the overproduction of reactive oxygen species and apoptosis." BMC systems biology 4, (2010): 135. [PubMed Link] | [ Full text ]
Fan, TW ; Yuan, P.; Lane, AN ; Higashi, RM ; Wang, Y.; Hamidi, AB ; Zhou, R.; Guitart, X.; Chen, G.; Manji, HK ; Kaddurah-Daouk, R. "Stable isotope-resolved metabolomic analysis of lithium effects on glial-neuronal metabolism and interactions." Metabolomics : Official journal of the Metabolomic Society 6, 2 (2010): 165-179. [PubMed Link] |
Lane, AN ; Fan, TW ; Xie, Z.; Moseley, HN ; Higashi, RM "Isotopomer analysis of lipid biosynthesis by high resolution mass spectrometry and NMR." Analytica chimica acta 651, 2 (2009): 201-8. [PubMed Link] | [ Full text ]
Fan, TW ; Lane, AN ; Higashi, RM ; Farag, MA ; Gao, H.; Bousamra, M.; Miller, DM "Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM)." Molecular cancer 8, (2009): 41. [PubMed Link] | [ Full text ]
Lane, AN ; Fan, TW ; Higashi, RM ; Tan, J.; Bousamra, M.; Miller, DM "Prospects for clinical cancer metabolomics using stable isotope tracers." Experimental and molecular pathology 86, 3 (2009): 165-73. [PubMed Link] | [ Full text ]
Fan, TW ; Lane, AN ; Higashi, RM ; Bousamra M, 2nd ; Kloecker, G.; Miller, DM "Metabolic profiling identifies lung tumor responsiveness to erlotinib." Experimental and molecular pathology 87, 1 (2009): 83-6. [PubMed Link] | [ Full text ]
Fan, TW ; Kucia, M.; Jankowski, K.; Higashi, RM ; Ratajczak, J.; Ratajczak, MZ ; Lane, AN "Rhabdomyosarcoma cells show an energy producing anabolic metabolic phenotype compared with primary myocytes." Molecular cancer 7, (2008): 79. [PubMed Link] | [ Full text ]
McNeely, SC ; Belshoff, AC ; Taylor, BF ; Fan, TW ; McCabe MJ, Jr ; Pinhas, AR ; States, JC "Sensitivity to sodium arsenite in human melanoma cells depends upon susceptibility to arsenite-induced mitotic arrest." Toxicology and applied pharmacology 229, 2 (2008): 252-61. [PubMed Link] | [ Full text ]
Lane, AN ; Fan, TW ; Higashi, RM "Stable isotope-assisted metabolomics in cancer research." IUBMB life 60, 2 (2008): 124-9. [PubMed Link] | [ Full text ]
Fan, T.; Elgourt, T. "Pain management pharmacy service in a community hospital." American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 65, 16 (2008): 1560-5. [PubMed Link] | [ Full text ]
Lane, AN ; Fan, TW ; Higashi, RM "Isotopomer-based metabolomic analysis by NMR and mass spectrometry." Methods in cell biology 84, (2008): 541-88. [PubMed Link] | [ Full text ]
Sumner, LW ; Amberg, A.; Barrett, D.; Beale, MH ; Beger, R.; Daykin, CA ; Fan, TW ; Fiehn, O.; Goodacre, R.; Griffin, JL ; Hankemeier, T.; Hardy, N.; Harnly, J.; Higashi, R.; Kopka, J.; Lane, AN ; Lindon, JC ; Marriott, P.; Nicholls, AW ; Reily, MD ; Thaden, JJ ; Viant, MR "Proposed minimum reporting standards for chemical analysis Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI)." Metabolomics : Official journal of the Metabolomic Society 3, 3 (2007): 211-221. [PubMed Link] |
Podrabsky, JE ; Lopez, JP ; Fan, TW ; Higashi, R.; Somero, GN "Extreme anoxia tolerance in embryos of the annual killifish Austrofundulus limnaeus: insights from a metabolomics analysis." The Journal of experimental biology 210, Pt 13 (2007): 2253-66. [PubMed Link] | [ Full text ]
MSI Board, Members. ; Sansone, SA ; Fan, T.; Goodacre, R.; Griffin, JL ; Hardy, NW ; Kaddurah-Daouk, R.; Kristal, BS ; Lindon, J.; Mendes, P.; Morrison, N.; Nikolau, B.; Robertson, D.; Sumner, LW ; Taylor, C.; Werf, M.; Ommen, B.; Fiehn, O. "The metabolomics standards initiative." Nature biotechnology 25, 8 (2007): 846-8. [PubMed Link] | [ Full text ]
Rose, WL ; Nisbet, RM ; Green, PG ; Norris, S.; Fan, T.; Smith, EH ; Cherr, GN ; Anderson, SL "Using an integrated approach to link biomarker responses and physiological stress to growth impairment of cadmium-exposed larval topsmelt." Aquatic toxicology (Amsterdam, Netherlands) 80, 3 (2006): 298-308. [PubMed Link] | [ Full text ]
Fan, TW ; Higashi, RM ; Lane, AN "Integrating metabolomics and transcriptomics for probing SE anticancer mechanisms." Drug metabolism reviews 38, 4 (2006): 707-32. [PubMed Link] | [ Full text ]
Teh, SJ ; Deng, X.; Deng, DF ; Teh, FC ; Hung, SS ; Fan, TW ; Liu, J.; Higashi, RM "Chronic effects of dietary selenium on juvenile Sacramento splittail (Pogonichthys macrolepidotus)." Environmental science & technology 38, 22 (2004): 6085-93. [PubMed Link] | [ Full text ]
Fan, TW ; Lane, AN ; Higashi, RM "An electrophoretic profiling method for thiol-rich phytochelatins and metallothioneins." Phytochemical analysis : PCA 15, 3 (2004): 175-83. [PubMed Link] | [ Full text ]
Fan, TW ; Lane, AN ; Higashi, RM "The promise of metabolomics in cancer molecular therapeutics." Current opinion in molecular therapeutics 6, 6 (2004): 584-92. [PubMed Link] |
Ramos, A.; Lane, AN ; Hollingworth, D.; Fan, TW "Secondary structure and stability of the selenocysteine insertion sequences (SECIS) for human thioredoxin reductase and glutathione peroxidase." Nucleic acids research 32, 5 (2004): 1746-55. [PubMed Link] | [ Full text ]
Fan, TW ; Teh, SJ ; Hinton, DE ; Higashi, RM "Selenium biotransformations into proteinaceous forms by foodweb organisms of selenium-laden drainage waters in California." Aquatic toxicology (Amsterdam, Netherlands) 57, 1-2 (2002): 65-84. [PubMed Link] | [ Full text ]