Hsin-Sheng Yang
Connect
859-323-6684Hsin-Sheng.Yang@uky.edu
1095 V A Drive
Positions
- Associate Professor
College Unit(s)
Other Affiliation(s)
- Markey Cancer Center
Biography and Education
Education
B.S., Tamkang University, Taiwan M.S. Tamkang University, Taiwan Ph.D. Arizona State University
Research
Dr. Yang's lab studies protein translational control of genes involved in tumor invasion and metastasis. Currently, we focus on investigating how Pdcd4 (Programed cell death 4), a novel tumor suppressor and a translation inhibitor, impacts on protein translation particularly the genes critical for tumor invasion and metastasis. Therefore, our research interests include:
- Elucidation of the signaling pathways impinged upon tumor invasion and metastasis
- Identification and characterization of novel factors involved in protein translation initiation
- Development and identification of novel agents or approaches for cancer therapeutics
Selected Publications
- Wang Q., J. Zhu, Y. Zhang, Z. Sun, X. Guo, X. Wang, E. Lee, V. Bakthavatchalu, Q. Yang, and H.-S. Yang. (2013). Down-regulation of Pdcd4 leads to epithelial to mesenchymal transition and promotes metastasis in nude mice. Eur. J. Cancer 49, 1761-1770. PMID: 23312883
- Wang Q., Y. Zhang, and H.-S. Yang. (2012). Pdcd4 knockdown up-regulates MAP4K1 expression and activation of AP-1 dependent transcription through c-Myc. Biochim. Biophys. Acta 1823, 1807-1814. PMID:22801218
- Guo, X., W. Li, Q. Wang, and H.-S. Yang. (2011). AKT activation by Pdcd4 knockdown upregulates cyclin D1 expression and promotes cell proliferation. Genes & Cancer 2, 818-828. PMCID: PMC3278903
- Wang, Q., Z. Sun, H. Allgayer, and H.-S. Yang. (2010). Down-regulation of E-cadherin is an essential event in activating β-catenin-dependent transcription and expression of its target genes in Pdcd4 knock-down cells. Oncogene 29, 128-138. PMCID: PMC2920641
- Loh, P. G., H.-S. Yang, M. Walsh, Q. Wang, X. Wang, Z. Cheng, D. Liu, and H. Song. (2009).Structural basis for translational inhibition by the tumor suppressor Pdcd4. EMBO J. 28, 274-285.
- Wang, Q., Z. Sun, and H.-S. Yang. (2008). Down-regulation of tumor suppressor Pdcd4 promotes invasion and activates both b-catenin/Tcf and AP-1 dependent transcription in colon carcinoma cells. Oncogene 27, 1527-1535.