What do we know about IDH1/2 mutations so far, and how do we use it?

A 29 year old woman with acute mental status changes.

Autophagy and oxidative stress in gliomas with IDH1 mutations.

Cofilin drives cell-invasive and metastatic responses to TGF-β in prostate cancer.

Sudemycin E influences alternative splicing and changes chromatin modifications.

Cancer stem cell-specific scavenger receptor CD36 drives glioblastoma progression.

ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.

Predicting the likelihood of an isocitrate dehydrogenase 1 or 2 mutation in diagnoses of infiltrative glioma.

Epidemiologic and molecular prognostic review of glioblastoma.

The tumor suppressor prostate apoptosis response-4 (Par-4) is regulated by mutant IDH1 and kills glioma stem cells.