What if a failed leukemia drug could reduce the risk of Alzheimer’s disease? A team at the University of Kentucky recently led an effort to investigate this hypothesis. Their results were published today in the journal, Human Molecular Genetics. The UK researchers, led by Steve Estus at the Sanders-Brown Center on Aging, study a genetic variant in a gene called CD33 that reduces the risk of Alzheimer’s disease. The Estus group recently published findings suggesting that this variant promotes production of a truncated form of the CD33 protein that lacks a putative functional domain. The CD33 protein is present on microglia, the resident immune cells of the brain. CD33... FULL STORY
Nathan Vanderford, assistant director for research at the University of Kentucky Markey Cancer Center and assistant professor in the Department of Toxicology and Cancer Biology, has a featured article on graduate education in the March 5 edition of Nature. Nature is one of the most prominent and prestigious interdisciplinary scientific journals in the world. Vanderford co-wrote an article titled, "Wanted: Information" with Viviane Callier from the Ronin Institute for Independent Scholarship. In the piece, Vanderford and Callier examine why recent doctoral graduates are having trouble obtaining jobs. They note that doctoral students, specifically those in the science... FULL STORY
Mary Vore was recently awarded the 2014 William R. Willard Award. This award is the College’s highest honor given to individuals who have made singular contributions to the College’s missions in research, teaching and service. Educated at Asbury College, Mary obtained her Ph.D. in pharmacology at Vanderbilt University. She returned to Kentucky as an Assistant Professor in the Department of Pharmacology and rose through the ranks to Professor in 1986. Beginning with her role as Vice-Chair, Mary displayed her administrative abilities and subsequently held a number of other positions leading up to her current roles as Director of the Graduate Center for Toxicology... FULL STORY
Growing up in the small rural town of Paintsville, Kentucky, Hilaree Frazier always loved science. She remembers that from a young age she was interested in pursing a PhD in science, but when she finished her bachelors of science at Eastern Kentucky University (EKU), she was intimidated by the prospect of going straight into a doctoral program. Even though she was interested in UK's Integrated Biomedical Sciences PhD program, she didn't apply. "I think I just didn't have enough confidence," she said. "There weren't a lot of opportunities in science in my hometown." Her undergraduate advisor at EKU suggested that she apply to a program a called the Kentucky Bridge... FULL STORY
The University of Kentucky Markey Cancer Center and the Leukemia and Lymphoma Society hosted their third annual "Meet the Researchers Day" on Tuesday. Meet the Researchers Day is a field trip given as a prize to two schools in the region who successfully raise more than $1,000 for the LLS's Pennies for Patients campaign. This year, students from Meece Middle School (MMS) in Somerset, Ky., and Lexington Traditional Magnet School (LTMS) won the opportunity to visit the Biomedical/Biological Sciences Research Building (BBSRB) on UK's campus and learned more about how the money they raised for Pennies for Patients will help further cancer research. After a formal... FULL STORY
The University of Kentucky Chapter of the International Federation of Medical Student Associations (IFMSA) will host the 10th annual Art of Healing silent auction on Wednesday, April 2. The auction will be held in Biological and Biomedical Sciences Research Building (BBSRB) atrium from noon to 5 p.m. Winning bidders may pick up their art from 5 p.m. to 6 p.m. The auction items feature the handiwork of local and international artists and current students, including pottery, paintings, wood carvings, and accessories. Proceeds from the art auction benefit the Shoulder to Shoulder clinic in Ecuador. Shoulder to Shoulder, an initiative supported by many of the... FULL STORY
Ana Bastos-Carvalho, a visiting scholar in the Ambati research group in the Department of Ophthalmology and Visual Sciences at the University of Kentucky College of Medicine, received the Global Ophthalmology Research Award from Bayer HealthCare for her research, "Mechanisms of geographic atrophy expansion in age-related macular degeneration." http://www.bayer-ophthalmology-awards.com/html/b-about-c.html “We are studying age-related macular degeneration (AMD), the disease responsible for most cases of legal blindness in the American elderly population”, Bastos-Carvalho said. “The project awarded by Bayer focuses on unraveling how AMD progresses, which will hopefully... FULL STORY
There's a proverb in the business world that says, "If you don’t know, hire someone who does." In the world of translational research, the saying might go like something this: "If you don't have the expertise or resources, collaborate with someone who does." The nature of translational science -- the process of turning a basic science discovery into applications for human patients -- is inherently multidimensional. Moving from the "bench to bedside" is a process that runs the gamut of biomedical research, incorporating laboratory and animal studies, clinical trials, drug and device development, regulatory issues, grant writing and more. Each step requires... FULL STORY
Congratulations to Joanne Collazo for passing her Ph.D. defense on Wednesday, 11/26/2013!
Everyone wants to be home for the holidays. Unfortunately, hospital patients don't have that luxury. For those who are unable to enjoy the comforts of a holiday at home, the UK Arts in Healthcare program has scheduled a series of events to help bring the holidays to the hospital. Carolers, pianists, harpists and more will bring holiday cheer to patients, visitors and staff in December. Of particular note: UK HealthCare's own Dr. Jay Zwischenberger will be performing at 1 p.m., Dec. 12, in the Pavilion A of UK Chandler Hospital. Carolers from Deep Springs Elementary School will be performing at noon, Dec.13, Pavilion A of UK Chandler Hospital. Carolers from the... FULL STORY
A new clinical trial being conducted at the University of Kentucky Sanders-Brown Center on Aging (SBCoA) and the UK Alzheimer’s Disease Center (ADC) may signal new hope in the future for those who might be afflicted with the devastating disease. Taking laboratory research pioneered at SBCoA and the associated UK ADC into human trials, the federally-funded research project will examine the therapeutic potential of microRNAs to delay or prevent Alzheimer’s disease.Led by physician-scientist Dr. Gregory Jicha, and building off of the work of fellow SBCoA physician-scientist Dr. Peter Nelson, the project, formally titled “Modulation of micro-RNA pathways by... FULL STORY
Congratulations to Cassandra Reiling for passing her Ph.D. defense in Toxicology on Friday, 11/15/2013!