Course Descriptions

IBS 601: Biomolecules and Metabolism (3)- An introductory graduate-level biochemistry course designed to provide a basic knowledge of molecular and biochemical principles necessary for advanced graduate study. Protein structure and function, enzyme catalysis, the generation and storage of metabolic energy, amino acid, nucleotide, and lipid metabolism and biological membranes and transport will be covered. Prerequisites: CHE 105 and 107, CHE 230 and 232, BIO 150 and 152, or equivalents. (Same as BCH 607.)

IBS 602: Molecular Biology & Genetics (3)- An introductory graduate-level course on mechanisms associated with DNA structure, replication, recombination and repair, chromatin, transcriptional control, mRNA processing, and protein synthesis. Aspects of contemporary genetics, genomics and bioinformatics will also be included. Techniques in genetic engineering and recombinant DNA that are critical to molecular biology research will be covered. Prerequisites: CHE 105 and 107, CHE 230 and 232, BIO 150 and 152, or equivalents.

IBS 603: Cell Biology & Cell Signaling(3)- An introductory graduate level course that is focused on a number of topics related to cell biology including cell types and cell architecture/organization, membrane structure, cytoskeleton, nucleus and mitochondria. Aspects of development, cell division, cell cycle and apoptosis will also be discussed with an emphasis on signaling pathways controlling these processes. Prerequisites: CHE 105 and 107, CHE 230 and 232, BIO 150 and 152, or equivalents.

IBS 606: Physiological Communications (3)- An introductory graduate level course that considers the function of the mammalian organism from a perspective ranging from cells to organs, with an emphasis on physiological communication between organ systems. The course is organized into 3 sections that include: (a) overview of basic physiological mechanisms maintaining homeostasis and mechanisms of endocrine communication via the bloodstream, (b) mechanisms of cell to cell communication by the immune system, and (c) mechanisms of neural communication. Prerequisites: IBS601 and IBS02.

IBS 608: Special Topics in IBS (2)- A graduate level course comprised of ½ credit mini-courses, each meeting for one hour/week for seven weeks, with each student participating in four mini-courses during the semester. Each mini-course will focus on a specific topic or area of research that is ongoing at UK or is particularly timely/exciting, and taught by faculty in the seven IBS departments. Up to ten mini-courses will be offered; students will be expected to sign up for six mini-courses in order of preference and will be assigned to four mini-courses. Prerequisites: IBS601 and IBS02.

IBS 610: Critical Reading/Small Groups (2)- A graduate level course emphasizing the student's ability to critically read, evaluate and critique papers in the areas of biochemistry, molecular biology and genetics. Students in each small group will meet weekly for two hours with one faculty member during the course of the semester and will be expected to read and be prepared to discuss papers during class meetings. Topics and concepts being discussed in both the readings and small group meetings will often coincide with topics being covered in IBS 601 and/or IBS 602. Perquisites: Have taken or concurrently taking IBS 601 and IBS 602.

IBS 611: Practical Statistics (1)- An introductory graduate level course that will introduce students to basic statistical concepts and applications that are used in a majority of biomedical and translational research studies. The emphasis will be on “how” and “why” certain basic statistical applications are used rather than the theory behind various statistical methods. Prerequisites: Have taken or concurrently taking IBS601 and IBS602.

IBS 607: Seminar in Integrated Biomedical Sciences (0)- Weekly seminar devoted to the presentation and discussion of classic and new research. May be repeated. Two semesters required as part of IBS Curriculum. Prerequisites: Admission to IBS Curriculum (non-IBS Students may not register for this course).

IBS 609: Research in Integrated Biomedical Sciences (1)- Individualized laboratory and research experience under the supervision of a faculty member. May be repeated to a maximum of 2 credit hours. Two semesters required as part of IBS Curriculum. Prerequisites: Admission to IBS Curriculum and consent of instructor (non-IBS Students may not register for this course).

TOX 600: Ethics in Scientific Research (1) -The course will commence with an overview of good laboratory practices and present them as the basis of good scientific research, along with an overview of quality assurance and appropriate practices in data analysis and data interpretation. The course will then move to the ethics of human and animal experimentation and discuss the concepts of data and intellectual property, their ownership and access to them. The problems of reviewing other workers' intellectual property such as grant applications, research papers and other intellectual property will be addressed.

TOX663: Drug Metabolism and Disposition (2)-Presentation of basic and advanced concepts in toxicology, with a specific focus on how toxins are absorbed, distributed throughout the body, metabolized, and excreted (ADME). The class is comprised of traditional didactic lectures and small group discussions about current topics and papers. In addition, the toxicological implications of pharmaceutical drugs and local, KY, environmental toxins are discussed. At the end of this class students should be able to create reasonable hypothesis as to how various toxins are dealt with by the human body.

TOX 680: Molecular Mechanism in Toxicology (5)- An intensive examination of the chemistry and action of substances which adversely affect living systems, and consideration of means of lessening their impact on man and the environment.

TOX 770-001: Toxicology Seminar (0-1)- A specialized seminar focusing on current topics of toxicological significance. Registration each fall and spring semester required of all toxicology graduate students until residency requirements for the degree have been completed. Graduate Students presenting a seminar may sign up for one credit. May be repeated to a maximum number of two credits during entire graduate course work. Graduate students not presenting a seminar should enroll for zero credits.

TOX 770-002: Journal Club for First Year Toxicology Students (1)-Journal Club is a specialized seminar for first year graduate students, intended to introduce them to campus resources available to them and to acquaint them with the current toxicology literature.

TOX 780: Special Problems in Toxicology /Grant Writing (2)- Exposure to and actual research experience in an area of toxicology other than that encountered by students in their thesis and dissertation research.